Expression and Localization of E-Cadherin in Epithelial Ovarian Cancer

被引：0
|
作者：
Koensgen, Dominique [2 ]
Freitag, Cornelia [1 ]
Klaman, Irina [3 ]
Dahl, Edgar [4 ]
Mustea, Alexander [2 ]
Chekerov, Radoslav [1 ]
Braicu, Ioana [1 ]
Lichtenegger, Werner [1 ]
Sehouli, Jalid [1 ]
机构：
[1] Charite, Campus Virchow Clin, Dept Gynecol, D-13353 Berlin, Germany
[2] Ernst Moritz Arndt Univ Greifswald, Hosp Greifswald, Dept Gynecol & Obstet, D-17475 Greifswald, Germany
[3] Signature Diagnost AG, D-14469 Potsdam, Germany
[4] Univ Hosp, Rhein Westfal TH Aachen, Inst Pathol, D-52074 Aachen, Germany
来源：
ANTICANCER RESEARCH | 2010年 / 30卷 / 07期
关键词：
E-Cadherin; ovarian cancer; expression; prognosis; CELL-ADHESION; SURFACE EPITHELIUM; BETA-CATENIN; CARCINOMAS; PROGRESSION; RECEPTORS; TUMORS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Findings for the role of E-cadherin in ovarian cancer (OC) are controversial. The aim of this study was to analyze the expression and prognostic role of E-cadherin in OC. Materials and Methods: Expression analysis of E-cadherin was performed by immunohistochemistry in 36 patients (12 primary OC, 15 recurrent OC, 9 benign ovarian lesions). Tumor specimens were collected within OC. Correlation analysis with clinicopathological factors and survival was performed. Results: E-Cadherin was significantly reduced in OC compared to benign ovarian lesions (p=0.024). In primary OC, E-cadherin was comparable in ovarian tumor and corresponding metastatic tumor tissue. E-Cadherin showed no association with clinicopathological factors. A significant correlation between increased volume of ascites and higher E-cadherin immunoexpression was found in primary OC (p=0.029). E-Cadherin expression showed no statistically prognostic significance for survival (p=0.856). Conclusion: The function of E-cadherin in OC remains controversial and needs to be elucidated further in larger studies.
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收藏
页码：2525 / 2530
页数：6
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