Expression and Localization of E-Cadherin in Epithelial Ovarian Cancer

被引：0

作者：

Koensgen, Dominique ^{[2
]}

Freitag, Cornelia ^{[1
]}

Klaman, Irina ^{[3
]}

Dahl, Edgar ^{[4
]}

Mustea, Alexander ^{[2
]}

Chekerov, Radoslav ^{[1
]}

Braicu, Ioana ^{[1
]}

Lichtenegger, Werner ^{[1
]}

Sehouli, Jalid ^{[1
]}

机构：

[1] Charite, Campus Virchow Clin, Dept Gynecol, D-13353 Berlin, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Hosp Greifswald, Dept Gynecol & Obstet, D-17475 Greifswald, Germany

[3] Signature Diagnost AG, D-14469 Potsdam, Germany

[4] Univ Hosp, Rhein Westfal TH Aachen, Inst Pathol, D-52074 Aachen, Germany

来源：

ANTICANCER RESEARCH | 2010年 / 30卷 / 07期

关键词：

E-Cadherin; ovarian cancer; expression; prognosis; CELL-ADHESION; SURFACE EPITHELIUM; BETA-CATENIN; CARCINOMAS; PROGRESSION; RECEPTORS; TUMORS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Findings for the role of E-cadherin in ovarian cancer (OC) are controversial. The aim of this study was to analyze the expression and prognostic role of E-cadherin in OC. Materials and Methods: Expression analysis of E-cadherin was performed by immunohistochemistry in 36 patients (12 primary OC, 15 recurrent OC, 9 benign ovarian lesions). Tumor specimens were collected within OC. Correlation analysis with clinicopathological factors and survival was performed. Results: E-Cadherin was significantly reduced in OC compared to benign ovarian lesions (p=0.024). In primary OC, E-cadherin was comparable in ovarian tumor and corresponding metastatic tumor tissue. E-Cadherin showed no association with clinicopathological factors. A significant correlation between increased volume of ascites and higher E-cadherin immunoexpression was found in primary OC (p=0.029). E-Cadherin expression showed no statistically prognostic significance for survival (p=0.856). Conclusion: The function of E-cadherin in OC remains controversial and needs to be elucidated further in larger studies.

引用

页码：2525 / 2530

页数：6

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