Chronic prenatal nicotine exposure alters enkephalin mRNA regulation in the perinatal rat adrenal medulla

被引：6
|
作者：
Wong, T [1 ]
Wickström, R [1 ]
Holgert, H [1 ]
机构：
[1] Karolinska Hosp, Dept Women & Child Hlth, Astrid Lindgren Childrens Hosp, Karolinska Inst, S-17176 Stockholm, Sweden
来源：
PEDIATRIC RESEARCH | 2003年 / 53卷 / 05期
关键词：
D O I：
10.1203/01.PDR.0000057985.43569.95
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Prenatal exposure to nicotine significantly increases enkephalin mRNA levels in the rat adrenal medulla prenatally, and postnatally the normal up-regulation is obliterated. This may lead to a disturbed modulation or regulation of catecholamine release in the adrenal and may be one factor contributing to the attenuated capacity of nicotine-treated pups to survive severe hypoxia. We speculate that this may be part of the mechanism underlying the relation between maternal smoking and sudden infant death syndrome.
引用
收藏
页码：814 / 816
页数：3
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