Recognition of 16 base pairs in the minor groove of DNA by a pyrrole-imidazole polyamide dimer

被引:100
|
作者
Trauger, JW [1 ]
Baird, EE [1 ]
Dervan, PB [1 ]
机构
[1] CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
关键词
D O I
10.1021/ja9800378
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:3534 / 3535
页数:2
相关论文
共 50 条
  • [41] Evaluation of the DNA Alkylation Properties of a Chlorambucil-Conjugated Cyclic Pyrrole-Imidazole Polyamide
    Hirose, Yuki
    Hashiya, Kaori
    Bando, Toshikazu
    Sugiyama, Hiroshi
    CHEMISTRY-A EUROPEAN JOURNAL, 2021, 27 (08) : 2782 - 2788
  • [42] Recognition of the four Watson–Crick base pairs in the DNA minor groove by synthetic ligands
    Sarah White
    Jason W. Szewczyk
    James M. Turner
    Eldon E. Baird
    Peter B. Dervan
    Nature, 1998, 391 : 468 - 471
  • [43] Strong and Specific Recognition of CAG/CTG Repeat DNA (5'-dWGCWGCW-3') by a Cyclic Pyrrole-Imidazole Polyamide
    Hirose, Yuki
    Ohno, Tomo
    Asamitsu, Sefan
    Hashiya, Kaori
    Bando, Toshikazu
    Sugiyama, Hiroshi
    CHEMBIOCHEM, 2022, 23 (02)
  • [44] A novel dicationic polyamide ligand binds in the DNA minor groove as a dimer
    Zhang, WT
    Dai, YQ
    Schmitz, U
    Bruice, TW
    FEBS LETTERS, 2001, 509 (01) : 85 - 89
  • [45] Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide
    Raskatov, Jevgenij A.
    Nickols, Nicholas G.
    Hargrove, Amanda E.
    Marinov, Georgi K.
    Wold, Barbara
    Dervan, Peter B.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (40) : 16041 - 16045
  • [46] Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairing in stacked polyamides
    Staples, A
    Uthe, P
    Buchmueller, K
    Bailey, S
    Nguyen, B
    Wilson, D
    Lee, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U164 - U164
  • [47] Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamides
    Buchmueller, KL
    Staples, AM
    Uthe, PB
    Howard, CM
    Pacheco, KAO
    Cox, KK
    Henry, JA
    Bailey, SL
    Horick, SM
    Nguyen, B
    Wilson, WD
    Lee, M
    NUCLEIC ACIDS RESEARCH, 2005, 33 (03) : 912 - 921
  • [48] Optimization of the hairpin polyamide design for recognition of the minor groove of DNA
    Parks, ME
    Baird, EE
    Dervan, PB
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (26) : 6147 - 6152
  • [49] Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif
    Kelly, JJ
    Baird, EE
    Dervan, PB
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (14) : 6981 - 6985
  • [50] A second-generation DNA-binding pyrrole-imidazole polyamide with antitumor activity.
    Nickols, Nicholas George
    Yang, Fei
    Li, Benjamin C.
    Szablowski, Jerzy O.
    Wang, Chieh-Mei
    Dervan, Peter Brendan
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)