In vitro investigation of Brazilian Cerrado plant extract activity against Plasmodium falciparum, Trypanosoma cruzi and T-brucei gambiense

被引：15

作者：

Charneau, Sebastien ^{[1
]}

de Mesquita, Mariana Laundry ^{[2
]}

Dourado Bastos, Izabela Marques ^{[3
]}

Santana, Jaime Martins ^{[3
]}

de Paula, Jose Elias ^{[4
]}

Grellier, Philippe ^{[5
]}

Espindola, Laila Salmen ^{[2
]}

机构：

[1] Univ Brasilia, Inst Ciencias Biol, Dept Biol Celular, Lab Bioquim Quim & Prot, Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil

[2] Univ Brasilia, Fac Ciencias Saude, Lab Farmacognosia, Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil

[3] Univ Brasilia, Inst Ciencias Biol, Dept Biol Celular, Lab Interacao Patogenohospedeiro, Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil

[4] Univ Brasilia, Inst Ciencias Biol, Lab Anat Vegetal, Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil

[5] Museum Natl Hist Nat, UMR CNRS 7245, Mol Commun & Adaptat Microorganismes, CP52,61 Rue Buffon, F-75231 Paris 05, France

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 11期

关键词：

anti-protozoal activity; malaria; Chagas disease; sleeping sickness; Brazilian Cerrado; Connarus suberosus; MEDICINAL-PLANTS; NATURAL-PRODUCTS; ESSENTIAL OIL; ANTIMALARIAL; DISCOVERY; LEAVES;

D O I：

10.1080/14786419.2015.1055264

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The threatened Brazilian Cerrado biome is an important biodiversity hotspot but still few explored that constitutes a potential reservoir of molecules to treat infectious diseases. We selected eight Cerrado plant species for screening against the erythrocytic stages of Plasmodium falciparum, human intracellular stages of Trypanosoma cruzi and bloodstream forms of T. brucei gambiense, and for their cytotoxicity upon the rat L6-myoblast cell line. Bioassays were performed with 37 hexane, ethyl acetate and ethanol extracts prepared from different plant organs. Activities against parasites were observed for 24 extracts: 9 with anti-P. falciparum, 4 with anti-T. cruzi and 11 with anti-T. brucei gambiense activities. High anti-protozoal activity (IC50 values<10g/mL) without obvious cytotoxicity to L6 cells was observed for eight extracts from plants: Connarus suberosus, Blepharocalyx salicifolius, Psidium laruotteanum and Myrsine guianensis. Overall, studies of plant extracts will contribute to increase the biodiversity knowledge essential for Cerrado conservation and sustainable development.

引用

页码：1320 / 1326

页数：7

共 31 条

[31] Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi
Jaen Batista, Denise da Gama
da Silva, Patricia Bernardino
Lachter, Daniela R.
Silva, Renata S.
Aucelio, Ricardo Q.
Louro, Sonia R. W.
Beraldo, Heloisa
Soeiro, Maria de Nazare C.
Teixeira, Leticia R.
POLYHEDRON, 2010, 29 (10) : 2232 - 2238

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