Assessment of the antitumor activity of a cyclopalladated ferrocene compound assisted by a dual-targeting drug delivery system

被引：17
|
作者：
Gong, Guidong [1 ]
Cao, Yuan [1 ]
Qian, Hongyun [1 ]
Zhou, Yangyang [1 ]
Zhao, Haihang [1 ]
Li, Ling [1 ]
Wang, Fei [2 ]
Zhao, Gang [1 ]
机构：
[1] Sichuan Univ, Coll Chem Engn, Chengdu 610064, Sichuan, Peoples R China
[2] Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu 610041, Sichuan, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 60期
基金：
中国国家自然科学基金;
关键词：
MITOCHONDRIAL-MEMBRANE; RECENT PROGRESS; CANCER-CELLS; DERIVATIVES; APOPTOSIS; REDOX; PERMEABILIZATION; NANOTECHNOLOGY; NANOPARTICLE; HYALURONAN;
D O I：
10.1039/c8cc03308k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
One cyclopalladated ferrocene compound CP was synthesized, which showed a good cell cytotoxicity. Assisted by a dual-targeting drug delivery system, the anticancer activity of CP to MDA-MB-468 remained unchanged, but the toxicity to non-tumorigenic cell line NIH3T3 was remarkably reduced. This provided a new path for the development of cyclopalladated ferrocene as an antitumor drug candidate.
引用
收藏
页码：8312 / 8315
页数：5
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