Assessment of the antitumor activity of a cyclopalladated ferrocene compound assisted by a dual-targeting drug delivery system

被引：17

作者：

Gong, Guidong ^{[1
]}

Cao, Yuan ^{[1
]}

Qian, Hongyun ^{[1
]}

Zhou, Yangyang ^{[1
]}

Zhao, Haihang ^{[1
]}

Li, Ling ^{[1
]}

Wang, Fei ^{[2
]}

Zhao, Gang ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem Engn, Chengdu 610064, Sichuan, Peoples R China

[2] Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu 610041, Sichuan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 60期

基金：

中国国家自然科学基金;

关键词：

MITOCHONDRIAL-MEMBRANE; RECENT PROGRESS; CANCER-CELLS; DERIVATIVES; APOPTOSIS; REDOX; PERMEABILIZATION; NANOTECHNOLOGY; NANOPARTICLE; HYALURONAN;

D O I：

10.1039/c8cc03308k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One cyclopalladated ferrocene compound CP was synthesized, which showed a good cell cytotoxicity. Assisted by a dual-targeting drug delivery system, the anticancer activity of CP to MDA-MB-468 remained unchanged, but the toxicity to non-tumorigenic cell line NIH3T3 was remarkably reduced. This provided a new path for the development of cyclopalladated ferrocene as an antitumor drug candidate.

引用

页码：8312 / 8315

页数：5