Allogeneic Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults

被引：3
|
作者：
Forman, Stephen J. [1 ,2 ]
机构：
[1] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA 91010 USA
[2] City Hope Canc Ctr, Dept Canc Immunotherapeut & Tumor Immunol, Duarte, CA 91010 USA
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 23卷 / 05期
关键词：
Acute lymphoblastic leukemia; Graft versus leukemia; Minimal residual disease; Philadelphia chromosome positive ALL; Precursor B cell ALL; Precursor T cell ALL; Total body irradiation; Reduced intensity transplant; BONE-MARROW-TRANSPLANTATION; TOTAL-BODY IRRADIATION; 1ST COMPLETE REMISSION; MINIMAL RESIDUAL DISEASE; DOSE CYTOSINE-ARABINOSIDE; MATCHED UNRELATED DONOR; VERSUS-HOST-DISEASE; HIGH-RISK; LALA-94; TRIAL; CLINICAL-SIGNIFICANCE;
D O I：
10.1016/j.hoc.2009.07.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acute lymphoblastic leukemia (ALL) is a hematologic malignancy of the bone marrow characterized by the rapid proliferation and subsequent accumulation of immature lymphocytes. ALL accounts for 20% of all acute leukemias that are seen in adults over the age of 20 years. In the past 2 decades, there has been substantial improvement in the understanding of the molecular biology of the disease and in the management of adult patients who have this disorder, including allogeneic transplantation This article reviews the biology of adult ALL, the relationship of specific disease characteristics to the natural history of the disease and the role of allogeneic hematopoietic cell transplantation in the management of adult patients with this disease.
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收藏
页码：1011 / +
页数：22
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