Allogeneic Hematopoietic Cell Transplantation in Adult Patients with Acute Lymphoblastic Leukemia

被引：15
|
作者：
Marks, David I. [1 ]
Alonso, Laura [1 ]
Radia, Rohini [1 ]
机构：
[1] Univ Hosp Bristol NHS Fdn Trust, Adult BMT Unit, Bristol BS2 8BJ, Avon, England
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 28卷 / 06期
关键词：
Acute lymphoblastic leukemia; Allogeneic hematopoietic cell transplantation; Timing of transplant; Pretransplant conditioning; Prognostic factors; MINIMAL RESIDUAL DISEASE; 1ST COMPLETE REMISSION; BONE-MARROW-TRANSPLANTATION; TOTAL-BODY IRRADIATION; 2ND COMPLETE REMISSION; IDENTICAL SIBLING TRANSPLANTATION; UNRELATED DONOR TRANSPLANTATION; ACUTE LYMPHOCYTIC-LEUKEMIA; REDUCED-INTENSITY; PROGNOSTIC-FACTORS;
D O I：
10.1016/j.hoc.2014.08.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This review discusses the use of prognostic factors, patient and donor selection, choice of conditioning regimens, and timing of transplant. It also describes the management of Philadelphia-positive acute lymphocytic leukemia (ALL) and central nervous system disease. All aggressively treated adults with ALL should be considered for allogeneic transplantation and tissue typed at diagnosis. We further suggest that eligible patients be entered into clinical trials (that incorporate transplantation); these unselected prospective outcome data are essential to evaluate the true value of allogeneic transplantation in adults with ALL.
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收藏
页码：995 / +
页数：16
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