The primary microcephaly 3 (MCPH3) interacting protein, p35 and its catalytic subunit, Cdk5, are centrosomal proteins

被引:15
|
作者
Rosales, Jesusa L. [3 ]
Rattner, Jerome B. [1 ,2 ]
Lee, Ki-Young [1 ,2 ]
机构
[1] Univ Calgary, Dept Cell Biol & Anat, So Alberta Canc Res Inst, Calgary, AB, Canada
[2] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada
[3] Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada
基金
加拿大健康研究院;
关键词
primary microcephaly; microcephalin (MCPH3); centrosome; Cdk5RAP2; p35; Cdk5; CYCLIN-DEPENDENT KINASE-5; BRAIN;
D O I
10.4161/cc.9.3.10597
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:618 / 620
页数:3
相关论文
共 50 条
  • [41] Distinct cellular compartment of cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activator protein (p35(nck5a)) in the developing rat cerebellum
    Matsushita, M
    Tomizawa, K
    Lu, YF
    Moriwaki, A
    Tokuda, M
    Itano, T
    Wang, JH
    Hatase, O
    Matsui, H
    BRAIN RESEARCH, 1996, 734 (1-2) : 319 - 322
  • [42] The role of CDK5 and its activators, p35/p39, in neuronal differentiation of PC12 cells.
    Choi, CH
    Aguanno, A
    FASEB JOURNAL, 2001, 15 (05): : A1167 - A1167
  • [43] Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells
    Nath, R
    Davis, M
    Probert, AW
    Kupina, NC
    Ren, XD
    Schielke, GP
    Wang, KKW
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 274 (01) : 16 - 21
  • [44] Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
    Quintanilla, RA
    Orellana, DI
    González-Billault, C
    Maccioni, RB
    EXPERIMENTAL CELL RESEARCH, 2004, 295 (01) : 245 - 257
  • [45] Protein kinase C zeta determines muscle differentiation through regulation of the Cdk5/p35/nestin signaling complex
    De Thone, A.
    Ferraris, S.
    Pallari, H.
    Salghren, C.
    Eriksson, J.
    DIFFERENTIATION, 2006, 74 (08) : 477 - 477
  • [46] CDK5 is Present in Sea Urchin and Starfish Eggs and Embryos and Can Interact With p35, Cyclin E and Cyclin B3
    Lozano, Jean-Claude
    Schatt, Philippe
    Verge, Valerie
    Gobinet, Jerome
    Villey, Vincent
    Peaucellier, Gerard
    MOLECULAR REPRODUCTION AND DEVELOPMENT, 2010, 77 (05) : 449 - 461
  • [47] Prenatal alcohol exposure alters p35, CDK5 and GSK3 beta in the medial frontal cortex and hippocampus of adolescent mice
    Goggin, Samantha L.
    Caldwell, Kevin K.
    Cunningham, Lee Anna
    Allan, Andrea M.
    TOXICOLOGY REPORTS, 2014, 1 : 544 - 553
  • [48] Cdk5/p25 inhibitory peptide (CIP) derived from p35 regulates Tau protein phosphorylation in transfected cells
    Zheng, YL
    Li, BS
    Amin, ND
    Pant, HC
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 11A - 11A
  • [49] Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway
    Sharma, P
    Veeranna
    Sharma, M
    Amin, ND
    Sihag, RK
    Grant, P
    Ahn, N
    Kulkarni, AB
    Pant, HC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (01) : 528 - 534
  • [50] Region specific expression of cyclin dependent kinase 5 (Cdk5) and its activators, p35 and p39 in developing and adult mouse brain
    Leung, CL
    Zheng, M
    Liem, RKH
    MOLECULAR BIOLOGY OF THE CELL, 1997, 8 : 105 - 105