A locus for congenital preauricular fistula maps to chromosome 8q11.1-q13.3

被引：15
|
作者：
Zou, FG
Peng, YC
Wang, XY
Sun, AH
Liu, WQ
Bai, SC
Zhu, H
Gao, B
Feng, GY
He, L
机构：
[1] Shanghai Jiao Tong Univ, Bio X Life Sci Res Ctr, Shanghai 200030, Peoples R China
[2] Chinese Acad Sci, Shanghai Res Ctr Life Sci, Shanghai, Peoples R China
[3] Shanghai Chang Zheng Hosp, Shanghai, Peoples R China
来源：
JOURNAL OF HUMAN GENETICS | 2003年 / 48卷 / 03期
关键词：
congenital preauricular fistula; linkage analysis; gene mapping; genotyping; haplotyping; mutation;
D O I：
10.1007/s100380300024
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The incidence of congenital preauricular fistula (CPF) is >1.1% in both Chinese and Caucasians, but it is even higher in Blacks. We mapped the locus for CPF to chromosome 8q11.1-q13.3 by linkage analysis of a family composed of 7 affected and 11 nonaffected members. The two-point LOD score was 2.40, shown by markers D8S285 and D8S1113 at a recombination fraction (0) of 0.00. Results from three other markers (D8S1110, D8S260, and D8S1136) in the same region further support the linkage. Haplotype analysis for this family confined the locus to within an interval of approximately 26.7cM, flanked by markers D8S532 and D8S279. A LOD score of <3 is likely due to the limitation of family size.
引用
收藏
页码：155 / 158
页数：4
相关论文
共 50 条
  • [21] A locus for migraine without aura maps on chromosome 14q21.2-q22.3
    Soragna, D
    Vettori, A
    Carraro, G
    Marchioni, E
    Vazza, G
    Bellini, S
    Tupler, R
    Savoldi, F
    Mostacciuolo, ML
    AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (01) : 161 - 167
  • [22] A locus for complicated spastic paraplegia maps to chromosome 1q24-q32
    Blumen, SC
    Bevan, S
    Abu-Mouch, S
    Negus, D
    Inzelberg, R
    Kahana, M
    Mazarib, A
    Carasso, RL
    Navon, R
    Withers, D
    Nisipeanu, P
    Reid, E
    ANNALS OF NEUROLOGY, 2003, 54 : S57 - S57
  • [23] A novel locus for parietal foramina maps to chromosome 4q21-q23
    Gang Chen
    Desan Zhang
    Guoying Feng
    Wanqing Liu
    Lin He
    Journal of Human Genetics, 2003, 48 : 420 - 424
  • [24] Autosomal recessive nonsyndromic deafness locus DFNB63 at chromosome 11q13.2-q13.3
    Khan, Shahid Y.
    Riazuddin, Saima
    Tariq, Muhammad
    Anwar, Saima
    Shabbir, Muhammad I.
    Riazuddin, S. Amer
    Khan, Shaheen N.
    Husnain, Tayyab
    Ahmed, Zubair M.
    Friedman, Thomas B.
    Riazuddin, Sheikh
    HUMAN GENETICS, 2007, 120 (06) : 789 - 793
  • [25] MAPPING A 5Q11.2-Q13.3 DELETION CHROMOSOME
    WOOD, S
    BERNARD, LE
    CYTOGENETICS AND CELL GENETICS, 1992, 61 (04): : 233 - 233
  • [26] A novel locus for syndromic chronic idiopathic intestinal pseudo-obstruction maps to chromosome 8q23-q24
    Deglincerti, Alessia
    De Giorgio, Roberto
    Cefle, Kivanc
    Devoto, Marcella
    Pippucci, Tommaso
    Castegnaro, Giovanni
    Panza, Emanuele
    Barbara, Giovanni
    Cogliandro, Rosanna F.
    Mungan, Zeynel
    Palanduz, Sukru
    Corinaldesi, Roberto
    Romeo, Giovanni
    Seri, Marco
    Stanghellini, Vincenzo
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2007, 15 (08) : 889 - 897
  • [27] Identification of a locus for punctate palmoplantar keratodermas at chromosome 8q24.13-8q24.21
    Zhang, XJ
    Li, M
    Gao, TW
    He, PP
    Wei, SC
    Liu, JB
    Li, CR
    Cui, Y
    Yang, S
    Yuan, WT
    Li, CY
    Liu, YF
    Xu, SJ
    Huang, W
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 122 (05) : 1121 - 1125
  • [28] A familial chordoma locus maps to chromosome 7q33.
    Yang, X
    Kelley, MJ
    Korczak, JF
    Sheridan, E
    Goldstein, AM
    Parry, DM
    AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (04) : 512 - 512
  • [29] Evidence that a locus for familial psoriasis maps to chromosome 4q
    Matthews, D
    Fry, L
    Powles, A
    Weber, J
    McCarthy, M
    Fisher, E
    Davies, K
    Williamson, R
    NATURE GENETICS, 1996, 14 (02) : 231 - 233
  • [30] A locus for primary ciliary dyskinesia maps to chromosome 19q
    Meeks, M
    Walne, A
    Spiden, S
    Simpson, H
    Mussaffi-Georgy, H
    Hamam, HD
    Fehaid, EL
    Cheehab, M
    Al-Dabbagh, M
    Polak-Charcon, S
    Blau, H
    O'Rawe, A
    Mitchison, HM
    Gardiner, RM
    Chung, E
    JOURNAL OF MEDICAL GENETICS, 2000, 37 (04) : 241 - 244
12345