Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate

被引：8
|
作者：
de Bruin, M [1 ]
van Capel, T [1 ]
Smid, K [1 ]
van der Born, K [1 ]
Fukushima, M [1 ]
Hoekman, K [1 ]
Pinedo, HM [1 ]
Peters, GJ [1 ]
机构：
[1] Vrije Univ Amsterdam, Dept Med Oncol, Med Ctr, NL-1081 HV Amsterdam, Netherlands
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2004年 / 23卷 / 8-9期
关键词：
platelet derived endothelial cell growth factor; thymidine phosphorylase; deoxyribose-1-phosphate; fluoropyrimidines;
D O I：
10.1081/NCN-200027702
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine (TdR) to thymine and deoxyribose-1-phosphate (dR-1-P). TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. We investigated the role of TP in 5'-deoxy-5-fluorouridine (5'DFUR), 5-fluorouracil (5FU) and trifluorothymidine (TFF) sensitivity. TP had no effect on TFT while it activated 5'DFUR and to a lesser extent 5FU. In order to provide an explanation for this difference in activation of 5'DFUR and 5FU, we studied the role of the 5FU co-substrate, dR-1-P, needed for its activation.
引用
收藏
页码：1485 / 1490
页数：6
相关论文
共 50 条
  • [31] The role of platelet derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) in prodrug activation in colon cancer cell lines.
    de Bruin, M
    Peters, GJ
    Hoekman, K
    Pinedo, HM
    [J]. CLINICAL CANCER RESEARCH, 2000, 6 : 4552S - 4552S
  • [32] Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers
    OBrien, TS
    Fox, SB
    Dickinson, AJ
    Turley, H
    Westwood, M
    Moghaddam, A
    Gatter, KC
    Bicknell, R
    Harris, AL
    [J]. CANCER RESEARCH, 1996, 56 (20) : 4799 - 4804
  • [33] Prognostic significance of thymidine phosphorylase/platelet-derived endothelial cell growth factor activity in renal cell carcinoma
    Mizutani, Y
    Nakanishi, H
    Ushijima, S
    Nakamura, T
    Nomoto, T
    Mikami, K
    Okihara, K
    Yoneda, K
    Kawauchi, A
    Miki, T
    [J]. JOURNAL OF UROLOGY, 2005, 173 (04): : 378 - 378
  • [34] Immunohistochemical expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in squamous cell carcinoma of the esophagus
    Koide, N
    Watanabe, H
    Yazawa, K
    Adachi, W
    Amano, D
    [J]. HEPATO-GASTROENTEROLOGY, 1999, 46 (26) : 944 - 951
  • [35] PLATELET-DERIVED ENDOTHELIAL-CELL GROWTH-FACTOR HAS THYMIDINE PHOSPHORYLASE-ACTIVITY
    USUKI, K
    SARAS, J
    WALTENBERGER, J
    MIYAZONO, K
    PIERCE, G
    THOMASON, A
    HELDIN, CH
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (03) : 1311 - 1316
  • [36] Thymidine phosphorylase (Platelet-derived endothelial cell growth factor) as a target for capecitabine: from biology to the bedside
    Ranieri, Girolamo
    Maria Roccaro, Aldo
    Vacca, Angelo
    Ribatti, Domenico
    [J]. RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2006, 1 (02) : 171 - 183
  • [37] Expression and localization of thymidine phosphorylase/platelet-derived endothelial cell growth factor in skin and cutaneous tumors
    Asgari, MM
    Haggerty, JG
    McNiff, JM
    Milstone, LM
    Schwartz, PM
    [J]. JOURNAL OF CUTANEOUS PATHOLOGY, 1999, 26 (06) : 287 - 294
  • [38] Tumor angiogenesis and expression: Of thymidine phosphorylase platelet derived endothelial cell growth factor in human gastric carcinoma
    Tanigawa, N
    Amaya, H
    Katoh, Y
    Kitaoka, A
    Aotake, T
    Shimomatsuya, T
    Rosenwasser, OA
    Iki, M
    [J]. CANCER LETTERS, 1996, 108 (02) : 281 - 290
  • [39] THYMIDINE PHOSPHORYLASE-ACTIVITY ASSOCIATED WITH PLATELET-DERIVED ENDOTHELIAL-CELL GROWTH-FACTOR
    SUMIZAWA, T
    FURUKAWA, T
    HARAGUCHI, M
    YOSHIMURA, A
    TAKEYASU, A
    ISHIZAWA, M
    YAMADA, Y
    AKIYAMA, S
    [J]. JOURNAL OF BIOCHEMISTRY, 1993, 114 (01): : 9 - 14
  • [40] Immunohistochemical detection of platelet-derived endothelial cell growth factor/thymidine phosphorylase and angiopoietins in ameloblastic tumors
    Kumamoto, Hiroyuki
    Ooya, Kiyoshi
    [J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2006, 35 (10) : 606 - 612
12345