Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate

被引：8

作者：

de Bruin, M ^{[1
]}

van Capel, T ^{[1
]}

Smid, K ^{[1
]}

van der Born, K ^{[1
]}

Fukushima, M ^{[1
]}

Hoekman, K ^{[1
]}

Pinedo, HM ^{[1
]}

Peters, GJ ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Med Oncol, Med Ctr, NL-1081 HV Amsterdam, Netherlands

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2004年 / 23卷 / 8-9期

关键词：

platelet derived endothelial cell growth factor; thymidine phosphorylase; deoxyribose-1-phosphate; fluoropyrimidines;

D O I：

10.1081/NCN-200027702

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine (TdR) to thymine and deoxyribose-1-phosphate (dR-1-P). TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. We investigated the role of TP in 5'-deoxy-5-fluorouridine (5'DFUR), 5-fluorouracil (5FU) and trifluorothymidine (TFF) sensitivity. TP had no effect on TFT while it activated 5'DFUR and to a lesser extent 5FU. In order to provide an explanation for this difference in activation of 5'DFUR and 5FU, we studied the role of the 5FU co-substrate, dR-1-P, needed for its activation.

引用

页码：1485 / 1490

页数：6

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