Treatment for the endocrine resistant breast cancer: Current options and future perspectives

被引：36
|
作者：
Liu, Chun-Yu [1 ,3 ]
Wu, Chia-Yun [1 ,3 ]
Petrossian, Karineh [4 ]
Huang, Tzu-Ting [1 ]
Tseng, Ling-Ming [2 ,3 ]
Chen, Shiuan [4 ]
机构：
[1] Dept Oncol, Div Med Oncol, Taipei, Taiwan
[2] Taipei Vet Gen Hosp, Dept Surg, Taipei, Taiwan
[3] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan
[4] City Hope Natl Med Ctr, Beckman Res Inst, Dept Canc Biol, 1500 East Duarte Rd, Duarte, CA 91010 USA
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2017年 / 172卷
关键词：
Endocrine resistance; Hormone receptor; Estrogen receptor; Breast cancer; ESTROGEN-RECEPTOR-ALPHA; GROWTH-FACTOR RECEPTOR; NONSTEROIDAL AROMATASE INHIBITORS; EVEROLIMUS PLUS EXEMESTANE; PENTOSE-PHOSPHATE PATHWAY; RANDOMIZED PHASE-II; HORMONE-RECEPTOR; POSTMENOPAUSAL WOMEN; DOUBLE-BLIND; TAMOXIFEN RESISTANCE;
D O I：
10.1016/j.jsbmb.2017.07.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endocrine resistance remains a challenge and an unmet need for managing hormone receptor-positive breast cancer. The mechanisms of endocrine resistance are multifaceted and are likely to evolve over time following various single or combination therapies. The purpose of this review article is to provide general understanding of molecular basis of endocrine resistance of breast cancer and to offer comprehensive review on current treatment options and potential new treatment strategies for endocrine resistant breast cancers. Last but not the least, we discuss current challenges and future directions for management of endocrine resistant breast cancers.
引用
收藏
页码：166 / 175
页数：10
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