Novel three-component reactions based on a Heck carbopalladation/cyclization domino reaction

被引：38
|
作者：
Kressierer, CJ [1 ]
Müller, TJJ [1 ]
机构：
[1] Univ Heidelberg, Inst Organ Chem, D-69120 Heidelberg, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 44期
关键词：
amination; C-C coupling; domino reactions; multicomponent reactions; olefination;
D O I：
10.1002/anie.200461134
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In one fell swoop: the reaction of alkynyl-allyl alcohols with aryl halides in the presence of [Pd(PPh3)2Cl2] under Heck reaction conditions provides cyclic γ,δ-enals (see scheme). This reaction serves as the starting sequence for the one-pot synthesis of diene esters and β-amino-substituted tetrahydrofurans.
引用
收藏
页码：5997 / 6000
页数：4
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