Efficient synthesis of pyrimidine carbonitriles and their derivatives

被引：9

作者：

Dolakova, Petra ^{[1
]}

Masojidkova, Milena ^{[1
]}

Holy, Antonin ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, Prague 16610 6, Czech Republic

来源：

HETEROCYCLES | 2007年 / 71卷 / 05期

关键词：

D O I：

10.3987/COM-07-11014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New approach to pyrimidinecarbonitriles was developed. Pyrimidine-4- and 6-carbonitriles were prepared by palladium-catalyzed cross-coupling reaction of iodopyrimidines with Zn(CN)2 in very good yields. The cyano group was converted into the corresponding acyl groups by the treatment with Grignard reagents and transformed to amido and imido function as well.

引用

页码：1107 / 1115

页数：9

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