Expression of cyclooxygenase mRNA in the livers of mice with interferon-γ chronic hepatitis

被引：2
|
作者：
Okamoto, T
Yamamura, K
Hino, O [1 ]
机构：
[1] Canc Inst, Dept Expt Pathol, Tokyo 1708455, Japan
[2] Kumamoto Univ, Sch Med, Int Mol Embryol & Genet, Kumamoto 8620976, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 2000年 / 83卷 / 04期
关键词：
transgenic mouse; cyclooxygenase; liver;
D O I：
10.1254/jjp.83.359
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Interferon-gamma (IFN-gamma) transgenic mice expressed the IFN-gamma gene in the liver and developed chronic hepatitis. The expression of cyclooxygenase (Cox)-1 and -2 mRNA were studied in the livers of these mice. A faint band of Cox-1 mRNA was observed in the livers of both normal and transgenic mice. Slight expression of Cox-2 mRNA was observed in the normal mouse liver, and this mRNA expression was induced in the transgenic mouse liver. The present results showed the induction of Cox-2 mRNA expression in the livers of transgenic mice with chronic hepatitis.
引用
收藏
页码：359 / 361
页数：3
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