Evaluation of serological diagnosis of Borna disease virus infection using recombinant proteins in experimentally infected rats

被引：11

作者：

Ogino, M

Yoshimatsu, K

Tsujimura, K

Mizutani, T

Arikawa, J

Takashima, I ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Dept Environm Vet Sci, Publ Hlth Lab, Sapporo, Hokkaido 060, Japan

[2] Hokkaido Univ, Sch Med, Inst Anim Experimentat, Sapporo, Hokkaido 060, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1998年 / 60卷 / 04期

关键词：

baculovirus; BDV; diagnosis;

D O I：

10.1292/jvms.60.531

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We produced two recombinant Borna disease virus (BDV) proteins, p40 and p24, by using a baculovirus vector as a diagnostic antigen; Antigenicities of these recombinant proteins were evaluated by immune rabbit sera; Recombinant p40 was a more sensitive antigen than p24 for the detection of antibodies in infected rats. Rats inoculated with BDV within 24 hi after birth showed higher detection rates of viral RNA and viral proteins from the brain than rats inoculated at 4 weeks-old. Depending on the age of infection and the time postinfection, the detection of BDV RNA, protein, or anti-BDV antibody did not always correlate in individuals, We suggest both serological and molecular biological methods are needed in the diagnosis of BDV infection.

引用

页码：531 / 534

页数：4

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