Structural basis for bifunctional peptide recognition at human δ-opioid receptor

被引：142

作者：

Fenalti, Gustavo ^{[1
]}

Zatsepin, Nadia A. ^{[2
]}

Betti, Cecilia ^{[3
,4
]}

Giguere, Patrick ^{[5
,6
,7
]}

Han, Gye Won ^{[1
]}

Ishchenko, Andrii ^{[1
]}

Liu, Wei ^{[1
]}

Guillemyn, Karel ^{[3
,4
]}

Zhang, Haitao ^{[1
]}

James, Daniel ^{[2
]}

Wang, Dingjie ^{[2
]}

Weierstall, Uwe ^{[2
]}

Spence, John C. H. ^{[2
]}

Boutet, Sebastien ^{[8
]}

Messerschmidt, Marc ^{[8
]}

Williams, Garth J. ^{[8
]}

Gati, Cornelius ^{[9
]}

Yefanov, Oleksandr M. ^{[9
]}

White, Thomas A. ^{[9
]}

Oberthuer, Dominik ^{[9
,10
]}

Metz, Markus ^{[9
,11
]}

Yoon, Chun Hong ^{[9
,12
]}

Barty, Anton ^{[9
]}

Chapman, Henry N. ^{[9
,11
]}

Basu, Shibom ^{[13
,14
]}

Coe, Jesse ^{[13
,14
]}

Conrad, Chelsie E. ^{[13
,14
]}

Fromme, Raimund ^{[13
,14
]}

Fromme, Petra ^{[13
,14
]}

Tourwe, Dirk ^{[3
,4
]}

Schiller, Peter W. ^{[15
]}

Roth, Bryan L. ^{[5
,6
,7
]}

Ballet, Steven ^{[3
,4
]}

Katritch, Vsevolod ^{[1
]}

Stevens, Raymond C. ^{[1
]}

Cherezov, Vadim ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA

[2] Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA

[3] Vrije Univ Brussel, Dept Chem, Brussels, Belgium

[4] Vrije Univ Brussel, Dept Bioengn Sci, Brussels, Belgium

[5] Univ N Carolina, Chapel Hill Med Sch, NIMH, Psychoact Drug Screening Program, Chapel Hill, NC USA

[6] Univ N Carolina, Chapel Hill Med Sch, Dept Pharmacol, Chapel Hill, NC USA

[7] Univ N Carolina, Chapel Hill Med Sch, Div Chem Biol & Med Chem, Chapel Hill, NC USA

[8] SLAC Natl Accelerator Lab, Linac Coherent Light Source, Menlo Pk, CA USA

[9] Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Hamburg, Germany

[10] Univ Hamburg, Inst Biochem & Mol Biol, Hamburg, Germany

[11] Univ Hamburg, Dept Phys, Hamburg, Germany

[12] European Xray Free Electron Laser Facil XFEL GmbH, Hamburg, Germany

[13] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ USA

[14] Arizona State Univ, Biodesign Inst, Ctr Appl Struct Discovery, Tempe, AZ USA

[15] Clin Res Inst Montreal, Lab Chem Biol & Peptide Res, Montreal, PQ H2W 1R7, Canada

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2015年 / 22卷 / 03期

基金：

美国国家卫生研究院; 加拿大健康研究院; 美国国家科学基金会;

关键词：

SERIAL FEMTOSECOND CRYSTALLOGRAPHY; MU AGONIST/DELTA ANTAGONIST; POTENT; TOLERANCE; DEPENDENCE; MORPHINE; BOND; DMT;

D O I：

10.1038/nsmb.2965

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bifunctional mu- and delta-opioid receptor (OR) ligands are potential therapeutic alternatives, with diminished side effects, to alkaloid opiate analgesics. We solved the structure of human delta-OR bound to the bifunctional delta-OR antagonist and mu-OR agonist tetrapeptide H-Dmt-Tic-Phe-Phe-NH2 (DIPP-NH2) by serial femtosecond crystallography, revealing a cis-peptide bond between H-Dmt and Tic. The observed receptor-peptide interactions are critical for understanding of the pharmacological profiles of opioid peptides and for development of improved analgesics.

引用

页码：265 / 268

页数：4

共 50 条

[41] Structural basis of peptide recognition and activation of endothelin receptors
Yujie Ji
Jia Duan
Qingning Yuan
Xinheng He
Gong Yang
Shengnan Zhu
Kai Wu
Wen Hu
Tianyu Gao
Xi Cheng
Hualiang Jiang
H. Eric Xu
Yi Jiang
Nature Communications, 14
[42] Structural basis of spirolactone recognition by the mineralocorticoid receptor
Huyet, Jessica
Pinon, Gory M.
Fay, Michel R.
Fagart, Ro Me
Rafestin-Oblin, Marie-Edith
MOLECULAR PHARMACOLOGY, 2007, 72 (03) : 563 - 571
[43] Structural basis for σ1 receptor ligand recognition
Hayden R. Schmidt
Robin M. Betz
Ron O. Dror
Andrew C. Kruse
Nature Structural & Molecular Biology, 2018, 25 : 981 - 987
[44] Structural basis for σ1 receptor ligand recognition
Schmidt, Hayden R.
Betz, Robin M.
Dror, Ron O.
Kruse, Andrew C.
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018, 25 (10) : 981 - +
[45] Structural basis of peptide recognition and activation of endothelin receptors
Ji, Yujie
Duan, Jia
Yuan, Qingning
He, Xinheng
Yang, Gong
Zhu, Shengnan
Wu, Kai
Hu, Wen
Gao, Tianyu
Cheng, Xi
Jiang, Hualiang
Xu, H. Eric
Jiang, Yi
NATURE COMMUNICATIONS, 2023, 14 (01)
[46] Structural basis for peptide recognition by archaeal oligopeptide permease A
Yokoyama, Hideshi
Kamei, Nanami
Konishi, Keijiro
Hara, Kodai
Ishikawa, Yoshinobu
Matsui, Ikuo
Forterre, Patrick
Hashimoto, Hiroshi
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2022, 90 (07) : 1434 - 1442
[47] The structural basis for the activation and peptide recognition of bacterial ClpP
Kim, Dong Young
Kim, Kyeong Kyu
JOURNAL OF MOLECULAR BIOLOGY, 2008, 379 (04) : 760 - 771
[48] Structural basis for receptor recognition by Lujo virus
Hadas Cohen-Dvashi
Itay Kilimnik
Ron Diskin
Nature Microbiology, 2018, 3 : 1153 - 1160
[49] Structural insights into peptide recognition of PTH receptor
Hashem, Shaima
Murail, Samuel
Tuffery, Pierre
JOURNAL OF PEPTIDE SCIENCE, 2024, 30
[50] The structural basis for peptide selection by the transport receptor OppA
Berntsson, Ronnie P-A
Doeven, Mark K.
Fusetti, Fabrizia
Duurkens, Ria H.
Sengupta, Durba
Marrink, Siewert-Jan
Thunnissen, Andy-Mark W. H.
Poolman, Bert
Slotboom, Dirk-Jan
EMBO JOURNAL, 2009, 28 (09): : 1332 - 1340

← 1 2 3 4 5 →