DNA ends: maintenance of chromosome termini versus repair of double strand breaks

被引：66
|
作者：
Lundblad, V [1 ]
机构：
[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2000年 / 451卷 / 1-2期
关键词：
telomeres; double strand breaks; DNA repair; survivor pathway; ALT mechanism;
D O I：
10.1016/S0027-5107(00)00052-X
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This review focuses on the factors that define the differences between the two types of DNA ends encountered by eukaryotic cells: telomeres and double strand breaks (DSBs). Although these two types of DNA termini are functionally distinct, recent studies have shown that a number of proteins is shared at telomeres and sites of DSB repair. The significance of these common components is discussed, as well as the types of DNA repair events that can compensate for a defective telomere. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：227 / 240
页数：14
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