Protection of C3HEB/FEJ mice against Leishmania amazonensis challenge after previous Leishmania major infection

被引：16
|
作者：
Vanloubbeeck, Y [1 ]
Jones, DE [1 ]
机构：
[1] Iowa State Univ, Coll Vet Med, Dept Vet Pathol, Ames, IA 50011 USA
来源：
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2004年 / 71卷 / 04期
关键词：
D O I：
10.4269/ajtmh.2004.71.407
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The Th1 response elicited in mice infected with Leishmania major has been used as a model to characterize cellular immune defects associated with L. amazonensis infection. However, it is not known if the immune response associated with the infection by virulent L. major parasites can promote resistance to a subsequent L. amazonensis infection. Our data demonstrate that C3HeB/FeJ mice infected subcutaneously with virulent L. major are resistant to an L. amazonensis challenge. The healing phenotype is characterized by a Th1 response as measured by increased production of interferon-gamma and low levels of interleukin-4 in the draining lymph node. Together, this indicates that the Th1 response associated with L. major infection can promote resistance to L. amazonensis infection and that it can be used as a tool to study the immune defects associated with L. amazonensis infection.
引用
收藏
页码：407 / 411
页数：5
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