Diagnostic value of real-time shear wave elastography in children with chronic kidney disease

OBJECTIVE: To evaluate the diagnostic value of real-time shear wave elastography (SWE) in children with chronic kidney disease (CKD). METHODS: Children with CKD diagnosed by the ultrasound-guided biopsy between January 2018 and May 2019 were enrolled as the case group. Age- and sex- matched healthy children were selected as the control group. The Young's Modulus (YM) of the renal cortexwas measured by SWE after the traditional ultrasound examination. Variance analysiswas performed to compare the values of YM between the two groups. Receiver operating characteristic curve (ROC) analysis was used to compare the values of YM, and explore the cut-offs of the YM. RESULTS: In the case group (n = 60, 45% male, mean age of 9.2 years), the kidney YMmodulus on the left side (16.8 +/- 4.8 kPa vs. 8.3 +/- 2.1 kPa) and the right side (16.0 +/- 4.7 kPa vs. 8.3 +/- 2.4 kPa) were both higher than the control group (all P values < 0.001). With the progress of CKD, the YM value of the left and right kidneys gradually increased. ROC analysis showed that when the left and right kidney YM value was 11.7 kPa and 11.0 kPa, the diagnostic sensitivity and specificity were the highest (left: respectively 93.3% and 95.0%; right: respectively 93.3 % and 91.7%). CONCLUSION: The increase of YM in CKD is related to the progression of renal dysfunction which may provide a new method for early diagnosis of CKD, dynamic monitoring of disease progression, and evaluation of curative effect and prognosis.