Novel Melphalan and Chlorambucil Derivatives of 2,2,6,6-Tetramethyl-1-piperidinyloxy Radicals: Synthesis, Characterization, and Biological Evaluation in Vitro

被引：5

作者：

Zhao, Hongli ^{[1
,2
,3
]}

Meng, Xianjiang ^{[1
,2
]}

Yuan, Huihui ^{[1
,2
,3
]}

Lan, Minbo ^{[1
,2
,4
]}

机构：

[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, Inst Appl Chem, Shanghai 200237, Peoples R China

[4] E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 03期

关键词：

melphalan; chlorambucil; 2,2,6,6-tetramethyl-1-piperdinyloxy radical; cytotoxic activity; PIPERIDINE NITROXIDE TEMPOL; MUSTARD; CYTOTOXICITY; AGENTS; DNA;

D O I：

10.1248/cpb.58.332

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of spin-labeled melphalan and chlorambucil derivatives, coupling the alkylating agents with 2,2,6,6-tetra tetramethyl-1-piperidinyloxy (TEMPO) radicals, were synthesized, characterized, and their biological properties in vitro were evaluated. These compounds showed much higher cytotoxic activity against human leukemia cell line K562 in vitro than their parent compounds.

引用

页码：332 / 335

页数：4

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