Temperature-responsive P(NIPAM-co-NHMA)-grafted organic-inorganic hybrid hollow mesoporous silica nanoparticles for controlled drug delivery

Hollow mesoporous silica nanoparticles (HMSN) have been widely studied as drug delivery carriers due to their high drug loading capacity in the internal cavity. In this study, monodisperse and temperature-responsive hollow mesoporous silica nanoparticles (HMSN@P(NIPAM-co-NHMA)) were synthesized and investigated. HMSN and HMSN@P(NIPAM-co-NHMA) were characterized by SEM, TEM, FT-IR, TGA, XRD and nitrogen adsorptiondesorption isotherms. The results showed that the cross-linked temperature-sensitive polymer P(NIPAM-coNHMA) was grafted onto the surface of HMSN. Subsequently, using puerarin (PUE) as the drug model, the results demonstrated that the HMSN@P(NIPAM-co-NHMA) had an excellent loading efficiency and exhibited excellently temperature-sensitive release behavior. Furthermore, the biocompatibility and stability of HMSN and HMSN@P (NIPAM-co-NHMA) were studied by MTT assay and hemolysis assay, the results indicated HMSN@P(NIPAM-coNHMA) possessed excellent biocompatibility and stability. Thus, we have successfully synthesized HMSN@P (NIPAM-co-NHMA), and the drug release is temperature-responsive, which can realize controlled drug release.