Detection, Characterization, and Clinical Application of Mesenchymal Stem Cells in Periodontal Ligament Tissue

被引：40
|
作者：
Tomokiyo, Atsushi [1 ]
Yoshida, Shinichiro [1 ]
Hamano, Sayuri [2 ,3 ]
Hasegawa, Daigaku [1 ]
Sugii, Hideki [1 ]
Maeda, Hidefumi [1 ,2 ]
机构：
[1] Kyushu Univ Hosp, Div Endodont, Fukuoka, Fukuoka, Japan
[2] Kyushu Univ, Fac Dent Sci, Dept Endodontol & Operat Dent, Fukuoka, Fukuoka, Japan
[3] Kyushu Univ, OBT Res Ctr, Fukuoka, Fukuoka, Japan
来源：
STEM CELLS INTERNATIONAL | 2018年 / 2018卷
基金：
日本学术振兴会;
关键词：
HUMAN DENTAL-PULP; IMMUNOMODULATORY PROPERTIES; STROMAL CELLS; HUMAN GINGIVA; IN-VITRO; DIFFERENTIATION; FIBROBLASTS; PROLIFERATION; TRANSDIFFERENTIATION; REGENERATION;
D O I：
10.1155/2018/5450768
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal; therefore, they are considered as a highly promising stem cell population for tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSC population, and many researchers have isolated them and performed their detailed characterization. Here, we review the current understanding of the features and functions of MSC population in PDL tissues and discuss their possibility for the application of PDL regeneration.
引用
收藏
页数：9
相关论文
共 50 条
  • [41] Equine Bone Marrow and Adipose Tissue Mesenchymal Stem Cells: Cytofluorimetric Characterization, In Vitro Differentiation, and Clinical Application
    Iacono, Eleonora
    Merlo, Barbara
    Romagnoli, Noemi
    Rossi, Barbara
    Ricci, Francesca
    Spadari, Alessandro
    [J]. JOURNAL OF EQUINE VETERINARY SCIENCE, 2015, 35 (02) : 130 - 140
  • [42] Ovine Periodontal Ligament Stem Cells: Isolation, Characterization, and Differentiation Potential
    S. Gronthos
    K. Mrozik
    S. Shi
    P. M. Bartold
    [J]. Calcified Tissue International, 2006, 79 : 310 - 317
  • [43] Ovine periodontal ligament stem cells: Isolation, characterization, and differentiation potential
    Gronthos, S.
    Mrozik, K.
    Shi, S.
    Bartold, P. M.
    [J]. CALCIFIED TISSUE INTERNATIONAL, 2006, 79 (05) : 310 - 317
  • [44] Sources of Adult Mesenchymal Stem Cells for Ligament and Tendon Tissue Engineering
    Dhinsa, Baljinder S.
    Mahapatra, Anant N.
    Khan, Wasim S.
    [J]. CURRENT STEM CELL RESEARCH & THERAPY, 2015, 10 (01) : 26 - 30
  • [45] Mesenchymal Stem Cell Properties of Periodontal Ligament Cells From Deciduous and Permanent Teeth
    Silverio, Karina Gonzales
    Rodrigues, Thaisangela Lopes
    Dela Coletta, Ricardo
    Benevides, Luciana
    Da Silva, Joao Santana
    Casati, Marcio Zaffalon
    Sallum, Enilson Antonio
    Nociti, Francisco Humberto, Jr.
    [J]. JOURNAL OF PERIODONTOLOGY, 2010, 81 (08) : 1207 - 1215
  • [46] Comparison of periodontal ligament and gingiva-derived mesenchymal stem cells for regenerative therapies
    Santamaria, Silvia
    Sanchez, Nerea
    Sanz, Mariano
    Garcia-Sanz, Jose A.
    [J]. CLINICAL ORAL INVESTIGATIONS, 2017, 21 (04) : 1095 - 1102
  • [47] Comparison of periodontal ligament and gingiva-derived mesenchymal stem cells for regenerative therapies
    Silvia Santamaría
    Nerea Sanchez
    Mariano Sanz
    Jose A. Garcia-Sanz
    [J]. Clinical Oral Investigations, 2017, 21 : 1095 - 1102
  • [48] Cytokines differently define the immunomodulation of mesenchymal stem cells isolated from the periodontal ligament
    Behm, C.
    Blufstein, A.
    Gahn, J.
    Kubin, B.
    Moritz, A.
    Rausch-Fan, X.
    Andrukhov, O.
    [J]. CYTOTHERAPY, 2020, 22 (05) : S68 - S68
  • [49] Cementogenic potential of multipotential mesenchymal stem cells purified from the human periodontal ligament
    Torii, Daisuke
    Konishi, Kiyoshi
    Watanabe, Nobuyuki
    Goto, Shinichi
    Tsutsui, Takeki
    [J]. Odontology, 2015, 103 (01) : 27 - 35
  • [50] Cementogenic potential of multipotential mesenchymal stem cells purified from the human periodontal ligament
    Daisuke Torii
    Kiyoshi Konishi
    Nobuyuki Watanabe
    Shinichi Goto
    Takeki Tsutsui
    [J]. Odontology, 2015, 103 : 27 - 35
12345