The inhibition of nitric oxide synthase enhances PSA-NCAM expression and CREB phosphorylation in the rat hippocampus

被引：18
|
作者：
Park, C
Shin, KS
Ryu, JH
Kang, K
Kim, J
Ahn, H
Huh, Y
机构：
[1] Kyung Hee Univ, Coll Med, Med Sci & Engn Res Ctr React Oxygen Species, Dept Anat, Seoul 130701, South Korea
[2] Kyung Hee Univ, Grad Sch EW Med Sci, Dept Med Nutr, Seoul, South Korea
[3] Kyung Hee Univ, Coll Pharm, Dept Oriental Pharm, Seoul, South Korea
来源：
NEUROREPORT | 2004年 / 15卷 / 02期
关键词：
hippocampus; nitric oxide synthase (NOS); N-Nitro-L-arginine-methyl ester (NAME); phosphorylated cAMP response element binding; (pCREB) protein; polysialylated neural cell adhesion molecule (PSA-NCAM);
D O I：
10.1097/00001756-200402090-00003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It is well known that nitric oxide (NO) acts downstream of NMDA receptor activation, which regulates the neural plasticity in the brain. In the present study, the effect of L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor, on neural plasticity in the hippocampus was investigated. L-NAME increased the expression of PSA-NCAM and pCREB in the adult rat hippocampus. The colocalization of PSA-NCAM and pCREB indicates a possible relationship between the two in the granule cell layer in the dentate gyrus. Our results demonstrate that NO, as a subsignal of NMDA receptors, could be involved in the structural plasticity of the granule cell layer in the dentate gyrus by regulating the expression of PSA-NCAM and pCREB in the hippocampus.
引用
收藏
页码：231 / 234
页数：4
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