In vitro anticancer activity of extracts of Mentha Spp. against human cancer cells

被引：0
|
作者：
Sharma, Vikas [1 ]
Hussain, Shabir [1 ]
Gupta, Moni [1 ]
Saxena, Ajit Kumar [2 ]
机构：
[1] Sher E Kashmir Univ Agr Sci & Technol Jammu, Fac Basic Sci, Div Biochem, Jammu 180009, J&K, India
[2] Indian Inst Integrat Med, Canc Pharmacol Div, Jammu 180001, J&K, India
来源：
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS | 2014年 / 51卷 / 05期
关键词：
Mentha Spp; Cancer cells; SRB assay; CYTOTOXIC ACTIVITIES; ESSENTIAL OILS;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In vitro anticancer potential of methanolic and aqueous extracts of whole plants of Mentha arvensis, M. longifolia, M. spicata and M. viridis at concentration of 100 mu g/ml was evaluated against eight human cancer cell lines - A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1 and U-87MG from six different origins (breast, colon, glioblastoma, lung, leukemia and prostate) using sulphorhodamine blue (SRB) assay. Methanolic extracts of above-mentioned Mentha Spp. displayed anti-proliferative effect in the range of 70-97% against four human cancer cell lines, namely COLO-205, MCF-7, NCI-H322 and THP-1; however, aqueous extracts were found to be active against HCT-116 and PC-3. The results indicate that Mentha Spp. contain certain constituents with cytotoxic properties which may find use in developing anticancer agents.
引用
收藏
页码：416 / 419
页数：4
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