Platelet-derived growth factor in human brain tumors

被引：19

作者：

Kirsch, M

Wilson, JC

Black, P

机构：

[1] Harvard Univ, Childrens Hosp,Dept Surg,Neurosurg Labs, Brigham & Womens Hosp,Sch Med,Dept Neurosurg, Dana Farber Canc Inst,Joint Ctr Radiat Therapy, Boston, MA 02115 USA

[2] Harvard Univ, Childrens Hosp,Dept Surg,Brain Tumor Ctr, Brigham & Womens Hosp,Sch Med, Dana Farber Canc Inst,Joint Ctr Radiat Therapy, Boston, MA 02115 USA

[3] Tech Univ Dresden, Carl Gustav Carus Univ Klinikum, Klin & Poliklin Neurochirurg, Dresden, Germany

来源：

JOURNAL OF NEURO-ONCOLOGY | 1997年 / 35卷 / 03期

关键词：

D O I：

10.1023/A:1005872718547

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This paper initially reviews ligand and receptor systems for the PDGF family and the signalling systems they use as well as their role in neural developments. It then describes the putative role of this family in astrocytoma, meningioma, and pituitary adenoma pathogenesis. Potential therapies with receptor antagonists or dominant negative mutants are discussed in the final sections.

引用

页码：289 / 301

页数：13

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