Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability

被引:122
|
作者
Thivard, Lionel
Pradat, Pierre-Francois
Lehericy, Stephane
Lacomblez, Lucette
Dormont, Didier
Chiras, Jacques
Benali, Habib
Meininger, Vincent
机构
[1] Univ Paris 06, INSERM, U739, F-75013 Paris, France
[2] Hop La Pitie Salpetriere, Federat Malad Syst Nerveux, Paris, France
[3] Hop La Pitie Salpetriere, Dept Neuroradiol, Paris, France
[4] Hop La Pitie Salpetriere, Dept Pharmacol, Paris, France
[5] Hop La Pitie Salpetriere, CNRS, UPR640, LENA, Paris, France
[6] Univ Paris 06, INSERM, U678, F-75013 Paris, France
来源
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2007年 / 78卷 / 08期
关键词
CORTICOSPINAL TRACT DEGENERATION; EXTRAMOTOR INVOLVEMENT; NEURON INVOLVEMENT; BRAIN ATROPHY; ALS; MRI; PET;
D O I
10.1136/jnnp.2006.101758
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of this study was to investigate the extent of cortical and subcortical lesions in amyotrophic lateral sclerosis (ALS) using, in combination, voxel based diffusion tensor imaging (DTI) and voxel based morphometry (VBM). We included 15 patients with definite or probable ALS and 25 healthy volunteers. Patients were assessed using the revised ALS Functional Rating Scale (ALSFRS-R). In patients, reduced fractional anisotropy was found in bilateral corticospinal tracts, the left insula/ventrolateral premotor cortex, the right parietal cortex and the thalamus, which correlated with the ALSFRS-R. Increased mean diffusivity ( MD) was found bilaterally in the motor cortex, the ventrolateral premotor cortex/insula, the hippocampal formations and the right superior temporal gyrus, which did not correlate with the ALSFRS-R. VBM analysis showed no changes in white matter but widespread volume decreases in grey matter in several regions exhibiting MD abnormalities. In ALS patients, our results show that subcortical lesions extend beyond the corticospinal tract and are clinically relevant.
引用
收藏
页码:889 / 892
页数:4
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