SIMULATION OF MAGNETIC NANOPARTICLES IN BLOOD FLOW FOR MAGNETIC DRUG TARGETING APPLICATIONS

被引：1
|
作者：
Slabu, I [1 ,2 ]
Roeth, A. [3 ]
Guentherodt, G. [2 ]
Schmitz-Rode, T. [1 ]
Baumann, M. [1 ]
机构：
[1] Rhein Westfal TH Aachen, Helmholtz Inst, Fac Med, Appl Med Engn, Aachen, Germany
[2] Rhein Westfal TH Aachen, Phys Inst 2, Aachen, Germany
[3] Univ Hosp Aachen, Dept Gen Visceral & Transplantat Surg, Aachen, Germany
来源：
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK | 2013年 / 58卷
关键词：
SPIO; FEM; magnetic drug targeting;
D O I：
10.1515/bmt-2013-4039
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A new magnetic drug targeting model of placing an array of permanent magnets and coils inside hollow organs of the body was developed. This gives the possibility to target e. g. prostate carcinoma, oesophagus adenocarcinoma or bile duct Klatskin tumours with drugs bounded to magnetic nanoparticles. The targeting model uses FEM based simulations and describes the interaction of an external magnetic field with single suspended superparamagnetic iron oxide (SPIO) nanoparticles in blood flow, thereby, quantifying the amount of the accumulated SPIO at a vessel wall.
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页数：2
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