Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

被引：419
|
作者：
Kaneto, Hideaki [1 ]
Katakami, Naoto [1 ]
Matsuhisa, Munehide [1 ]
Matsuoka, Taka-aki [1 ]
机构：
[1] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka 5650871, Japan
来源：
MEDIATORS OF INFLAMMATION | 2010年 / 2010卷
关键词：
INSULIN GENE-TRANSCRIPTION; PANCREATIC BETA-CELLS; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED SIGNALING PATHWAYS; INTIMA-MEDIA THICKNESS; OXIDATIVE-STRESS; GLUCOSE TOXICITY; NAD(P)H OXIDASE; NITRIC-OXIDE; CAROTID ATHEROSCLEROSIS;
D O I：
10.1155/2010/453892
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic beta-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate beta-cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis.
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页数：11
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