Pan-cancer analysis of the DNA methylation patterns of long non-coding RNA

被引：6

作者：

Wang, Shijia ^{[1
,2
]}

Wang, Rendong ^{[1
,2
]}

Gao, Fang ^{[3
]}

Huang, Jun ^{[1
,2
]}

Zhao, Xiaoxiao ^{[1
,2
]}

Li, Dongguo ^{[1
,2
]}

机构：

[1] Capital Med Univ, Sch Biomed Engn, 10 You An Men Wai, Beijing 100069, Peoples R China

[2] Capital Med Univ, Beijing Key Lab Fundamental Res Biomech Clin Appl, Beijing 100069, Peoples R China

[3] Binzhou Peoples Hosp, Hlth Management Ctr, Binzhou, Shandong, Peoples R China

来源：

GENOMICS | 2022年 / 114卷 / 04期

关键词：

Pan-cancer; TCGA; DNA methylation; Long non-coding RNA; Co-expression network; CELL-PROLIFERATION; GENE; HYPOMETHYLATION; EPIGENETICS; PROGRESSION; ENRICHMENT; LANDSCAPE; INSIGHTS; LNCRNA;

D O I：

10.1016/j.ygeno.2022.110377

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Long non-coding RNA (lncRNA) regulated by abnormal DNA methylation (ADM-lncRNA) emerges as a biomarker for cancer diagnosis and treatment. This study comprehensively described the methylation patterns of lncRNA in pan-cancer using the cancer data set in The Cancer Genome Atlas (TCGA). Based on the cancer heterogeneity of ADM-lncRNA in pan-cancer, we constructed a co-expression network of pan-cancer ADM-lncRNA (pADMlncRNA) in 10 cancers, highlighting the combined action mode of abnormal DNA methylation, and indicating the internal connection among different cancers. Functional analysis revealed the pan-carcinogenic pathway of pADM-lncRNA and suggested potential factors for cancer heterogeneity and tumor immune microenvironment changes. Survival analysis showed the potential of pADM-lncRNA-mRNA co-expression pair as cancer biomarkers. Revealing the action mode of lncRNA and DNA methylation in cancer may help understand the key molecular mechanisms of cell carcinogenesis.

引用

页数：11

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