Design, Synthesis, Molecular Docking and Antimicrobial Activity of Novel Thiazolo[5,4-c]Pyridine Glycoside and Thiazolo[4,5-d]Pyrimidin Glycoside

In this research, we study here, the synthesis of 5-arylidenethiazolidin-4-one derivatives 5 which was used as a base for the synthesis of new thiazolo[4,5-d]thiopyrimidine derivatives and thiazolo[4,5-b] pyridine derivatives. New of their thioglycoside and N-glycoside derivatives were also studies. All the newly synthesized compounds exhibited high antimicrobial activity toward certain some microorganisms (bacteria and fungi). Some of these newly synthesized compounds were docked within the protein surface of 5AF1. The reports of this docking study revealed that the new compounds exhibit good antimicrobial activity. The structure of the newly synthesized compounds was characterized by spectral analysis such as IR spectrum, H-1 NMR spectrum, and C-13 HNMR spectrum.