Synthesis, Molecular Docking and Biological Properties of Novel Thiazolo [4,5-b] pyridine Derivatives

The synthesis, anti-inflammatory and antioxidant properties of novel 5-hydroxy-7-methyL-3H-thiazolo [4,5-b]pyridin-2-one derivatives were discussed. Fused thiazolo [4,5-b]pyridin-2-ones were synthesized and modified at the N-3, C-5 and C-6 positions of the main core in order to obtain the compounds with a satisfactory pharmacological profile. The synthesized compounds were preselected via molecular docking for further testing of their anti-inflammatory activity in vitro. Evaluation of novel compounds over the carageenin induced rat paw edema revealed strong anti-inflammatory action of some compounds including (thiazolo [4,5-b]pyridin-3(2H)-yl) propanenitrile (5) and thiazolo [4,5-b]pyridin-3(2H)-yl) propanoic acid (6) even exceeding the standard - Ibuprofen. The antioxidant activity of the synthesized compounds was measured in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.