Epigenetics of paediatric acute myeloid leukaemia

被引：13
|
作者：
Jones, Luke [1 ,2 ]
McCarthy, Peter [1 ,3 ]
Bond, Jonathan [1 ,2 ,3 ]
机构：
[1] Univ Coll Dublin, Sch Med, Syst Biol Ireland, Dublin, Ireland
[2] Natl Childrens Res Ctr, Dublin, Ireland
[3] Childrens Hlth Ireland Crumlin, Dublin, Ireland
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 188卷 / 01期
关键词：
epigenetics; acute myeloid leukaemia; Polycomb; paediatric; LONG NONCODING RNA; STEM-CELL FUNCTION; HEMATOPOIETIC STEM; PROGENITOR CELLS; TUMOR-SUPPRESSOR; OLDER PATIENTS; MUTANT IDH2; DNA; MUTATIONS; EZH2;
D O I：
10.1111/bjh.16361
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Comprehensive cataloguing of the acute myeloid leukaemia (AML) genome has revealed a high frequency of mutations and deletions in epigenetic factors that are frequently linked to treatment resistance and poor patient outcome. In this review, we discuss how the epigenetic mechanisms that underpin normal haematopoiesis are subverted in AML, and in particular how these processes are altered in childhood and adolescent leukaemias. We also provide a brief summary of the burgeoning field of epigenetic-based therapies, and how AML treatment might be improved through provision of better conceptual frameworks for understanding the pleiotropic molecular effects of epigenetic disruption.
引用
收藏
页码：63 / 76
页数：14
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