Paradoxical sleep deprivation modulates depressive-like behaviors by regulating the MAOA levels in the amygdala and hippocampus

被引:28
|
作者
Wang, Zhen [1 ]
Chen, Lu [2 ]
Zhang, Ling [1 ]
Wang, Xuemin [1 ]
机构
[1] Southern Med Univ, Sch Basic Med Sci, Dept Neurobiol, Key Lab Psychiat Disorders Guangdong Prov, Guangzhou 510000, Guangdong, Peoples R China
[2] South China Univ Technol, Affiliated Hosp 2, Pathol Dept, Guangzhou 510180, Guangdong, Peoples R China
关键词
Paradoxical sleep deprivation; Depressive-like behaviors; Amygdala; Hippocampus; Monoamine oxidase A; Phenelzine; OPEN-FIELD TEST; FORCED SWIMMING TEST; MONOAMINE-OXIDASE-A; PLUS-MAZE TEST; SUCROSE PREFERENCE; ANXIETY; ACTIVATION; STRESS; GENE; INSOMNIA;
D O I
10.1016/j.brainres.2017.03.022
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Paradoxical sleep is closely associated with depression, and brain monoamine oxidase A (MAOA) plays an important role in depression. However, the precise relationship between sleep and depression and the role of MAOA in this process remains unknown. Therefore, we established a paradoxical sleep deprivation model using the "multiple small platforms over water" protocol. Mice deprived of paradoxical sleep for 3 days showed no depressive-like behaviors; however, mice deprived of paradoxical sleep deprivation for 5 days (P5d) showed decreased locomotive activity in the first 3 days after P5d. Additionally, the P5d mice showed depressive-like behaviors one week after P5d, with a longer immobility time and a decreased sucrose preference rate. In addition, the levels of the MAOA protein and mRNA in the amygdala and hippocampus significantly increased. Furthermore, the immobility time and sucrose preference rate of P5d mice recovered when the mice were injected with phenelzine. The P5d mice displayed depressive like behaviors, which were likely modulated by the MAOA levels in the amygdala and hippocampus. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:17 / 24
页数:8
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