Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature

被引:21
|
作者
Campos-Martinez, Ana M. [1 ]
Exposito-Herrera, J. [1 ]
Gonzalez-Bolivar, M. [1 ]
Fernandez-Marin, E. [1 ]
Uberos, Jose [1 ,2 ]
机构
[1] San Cecilio Clin Hosp, Neonatal Intens Care Unit, Granada, Spain
[2] Med Fac, Pediat Dept, Granada, Spain
来源
FRONTIERS IN PEDIATRICS | 2022年 / 10卷
关键词
necrotizing enterocolitis; enteral nutrition; human milk; dysbiosis; probiotics; PROBIOTICS; PRETERM;
D O I
10.3389/fped.2022.874976
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Necrotizing enterocolitis (NEC) is a serious condition related to prematurity and the initiation of enteral feeding. In this article, we review the evidence published in recent years on necrotizing enterocolitis risk factors (prematurity, feeding with low-weight formula, existence of intestinal dysbiosis) and protective factors (human milk or donated milk supply, supplementation of human milk with oligosaccharides, probiotics administration, and the determination of disease predictive biomarkers). A systematic review was conducted of preventive, risk and predictive factors for necrotizing enterocolitis in neonates prior to 37 weeks' gestational age, based on a literature search for clinical trials, meta-analyses, randomized controlled trials and systematic reviews published between January 2018 and October 2021. For this purpose, the PubMed, MEDLINE, and Cochrane Library databases were consulted. The literature search obtained 113 articles, of which 19 were selected for further analysis after applying the inclusion and exclusion criteria. The conclusions drawn from this analysis were that adequate knowledge of risk factors that can be prevented or modified (such as alteration of the intestinal microbiota, oxidative stress, metabolic dysfunction at birth, or alteration of the immunity modulation) can reduce the incidence of NEC in premature infants. These factors include the supplementation of enteral nutrition with human milk oligosaccharides (with prebiotic and immunomodulatory effects), the combined administration of probiotics (especially the Lactobacillus spp and Bifidobacterium spp combination, which inhibits bacterial adhesion effects, improves the intestinal mucosa barrier function, strengthens the innate and adaptive immune system and increases the secretion of bioactive metabolites), the supplementation of human milk with lactoferrin and the use of donated milk fortified in accordance with the characteristics of the premature newborn. The determination of factors that can predict the existence of NEC, such as fecal calprotectin, increased TLR4 activity, and IL6 receptor, can lead to an early diagnosis of NEC. Although further studies should be conducted to determine the values of predictive biomarkers of NEC, and/or the recommended doses and strains of probiotics, lactoferrin or oligosaccharides, the knowledge acquired in recent years is encouraging.
引用
收藏
页数:8
相关论文
共 50 条
  • [31] Prevention of necrotizing enterocolitis in premature infants——an updated review
    Yu-Ting Jin
    Yue Duan
    Xiao-Kai Deng
    Jing Lin
    World Journal of Clinical Pediatrics, 2019, 8 (02) : 23 - 32
  • [32] Are anemia and red blood cell transfusion risk factors for necrotizing enterocolitis in premature infants?
    Naveda Romero, O.
    Naveda Melendez, A.
    BOLETIN DE PEDIATRIA, 2015, 55 (231): : 3 - 9
  • [33] NECROTIZING ENTEROCOLITIS AND KLEBSIELLA COLONIZATION OF HIGH-RISK NEWBORNS
    SWARNER, CW
    BARNES, FM
    QUILLIGAN, JJ
    PEDIATRIC RESEARCH, 1976, 10 (04) : 433 - 433
  • [34] EARLY POSTNATAL STEROID USE IN PREMATURE INFANTS AND THE RISK FOR NECROTIZING ENTEROCOLITIS: A COMPREHENSIVE REVIEW
    Heredia, G.
    Patel, A.
    Chung, C.
    Yao, J.
    Sahrai, K.
    Sathe, P.
    Michael, Y.
    Afghani, B.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2016, 64 (01) : 335 - 335
  • [35] Perforated neonatal appendicitis mimicking necrotizing enterocolitis in a premature neonate: a case report and literature review
    Manasra, Mahmoud R.
    Alhroob, Thaer
    Marrawani, Mohammad
    Batanje, Dalia
    Imran, Yahya
    Harahsha, Moatz
    Amleh, Abdul-Karim
    Zugayar, Diaa
    JOURNAL OF SURGICAL CASE REPORTS, 2024, 2024 (07):
  • [36] Serum Markers of Necrotizing Enterocolitis: A Systematic Review
    Terrin, Gianluca
    Stronati, Laura
    Cucchiara, Salvatore
    De Curtis, Mario
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2017, 65 (06): : E120 - E132
  • [37] The microbiome of newborns. A literature review of the current understanding of neonatalmicrobiome research
    Werzin, Lisa-Maria
    Resch, Bernhard
    PADIATRIE UND PADOLOGIE, 2015, 50 (04): : 160 - 164
  • [38] Necrotizing Enterocolitis: A Narrative Review of Updated Therapeutic and Preventive Interventions
    Reid, Brittany Michelle
    Thompson-Branch, Alecia
    JOURNAL OF PEDIATRICS REVIEW, 2016, 4 (02)
  • [39] Establishment and evaluation of three necrotizing enterocolitis models in premature rats
    Zhou, Wei
    Zheng, Xiao-Hui
    Rong, Xiao
    Huang, Long-Guang
    MOLECULAR MEDICINE REPORTS, 2011, 4 (06) : 1333 - 1338
  • [40] Correlative Factors of the Deterioration of Necrotizing Enterocolitis in Small for Gestational Age Newborns
    Luo, Lijuan
    Dong, Wenbin
    Zhang, Lingping
    Zhai, Xuesong
    Li, Qingping
    Lei, Xiaoping
    SCIENTIFIC REPORTS, 2018, 8