Inhibition of tumor necrosis factor-α-induced apoptosis by Asparagus cochinchinensis in Hep G2 cells

被引：34
|
作者：
Koo, HN
Jeong, HJ
Choi, JY
Choi, SD
Choi, TJ
Cheon, YS
Kim, KS
Kang, BK
Park, ST
Chang, CH
Kim, CH
Lee, YM
Kim, HM
An, NH
Kim, JJ
机构：
[1] Wonkwang Univ, Ctr Oriental Med Sci, Sch Med, Dept Anat, Chonbuk 570749, South Korea
[2] Wonkwang Univ, Ctr Oriental Med Sci, Sch Med, Coll Pharm, Chonbuk 570749, South Korea
[3] Wonkwang Univ, Ctr Oriental Med Sci, Sch Med, Dept Internal Med, Chonbuk 570749, South Korea
[4] Wonkwang Univ, Ctr Oriental Med Sci, Sch Med, Dept Otolaryngol Head & Neck Surg, Chonbuk 570749, South Korea
[5] DongGuk Univ, Coll Oriental Med, Dept Biochem & Mol Biol, Kyungju City 780714, Kyungpook, South Korea
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 73卷 / 1-2期
关键词：
Asparagus cochinchinensis(MERRIL) (Liliaceae) roots; Hep G2 cells; ethanol; tumor necrosis factor-alpha; cytotoxicity; apoptosis;
D O I：
10.1016/S0378-8741(00)00287-7
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A human hepatoma cell line, Hep G2 cells, is a reliable system for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Asparagus cochinchinensis(MERRIL) (Liliaceae) roots (ACAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. ACAE (1-100 mug/ml) dose-dependently inhibited the EtOH-induced tumor necrosis factor-alpha (TNF-alpha) secretion. ACAE (1-100 mug/ml) also inhibited the EtOH and TNF-alpha -induced cytotoxicity. Furthermore, we found that ACAE inhibited the TNF-alpha -induced apoptosis of Hep G2 cells. These results suggest that ACAE may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells. (C) 2000 Published by Elsevier Science Ireland Ltd.
引用
收藏
页码：137 / 143
页数：7
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