Head and neck cancer;
IGRT;
Laryngeal sparing;
INTENSITY-MODULATED RADIOTHERAPY;
RADIATION-THERAPY;
HELICAL TOMOTHERAPY;
NASOPHARYNGEAL CARCINOMA;
IMRT;
DYSPHAGIA;
CHEMORADIATION;
FIELD;
D O I:
10.1016/j.oraloncology.2010.01.010
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes. (C) 2010 Elsevier Ltd. All rights reserved.
机构:
Ctr Rene Gauducheau, Serv Phys Med, F-44805 St Herblain, FranceInst Gustave Roussy, Dept Radiotherapie, F-94805 Villejuif, France
Lisbona, A.
Bodez, V.
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机构:
Inst St Catherine, Serv Phys Med, F-84000 Avignon, FranceInst Gustave Roussy, Dept Radiotherapie, F-94805 Villejuif, France
Bodez, V.
Marguet, M.
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机构:
Inst St Catherine, Serv Phys Med, F-84000 Avignon, FranceInst Gustave Roussy, Dept Radiotherapie, F-94805 Villejuif, France
Marguet, M.
Lafay, F.
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机构:
Ctr Leon Berard, Unite Radiophys, F-69008 Lyon, FranceInst Gustave Roussy, Dept Radiotherapie, F-94805 Villejuif, France
Lafay, F.
Remonnay, R.
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机构:
Ctr Leon Berard, LASS CNRS, FRE 2747, GRESAC, F-69008 Lyon, FranceInst Gustave Roussy, Dept Radiotherapie, F-94805 Villejuif, France
Remonnay, R.
Lagrange, J. -L.
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机构:
Univ Paris 12, Hop Henri Mondor, AP HP, Dept Radiotherapie,Inserm EMI 0337, F-94000 Creteil, FranceInst Gustave Roussy, Dept Radiotherapie, F-94805 Villejuif, France
机构:
Univ Penn, Sch Med, Dept Radiol, Div Neuradiol, Philadelphia, PA 19104 USA
Hosp Univ Penn, Philadelphia, PA 19104 USAUniv Penn, Sch Med, Dept Radiol, Div Neuradiol, Philadelphia, PA 19104 USA