Uric acid in chronic coronary syndromes: Relationship with coronary artery disease severity and left ventricular diastolic parameter
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作者:
Maloberti, Alessandro
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Milano Bicocca Univ, Sch Med & Surg, Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Maloberti, Alessandro
[1
,2
]
Bossi, Irene
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 1, Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Bossi, Irene
[3
]
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Tassistro, Elena
[4
]
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Rebora, Paola
[4
]
Racioppi, Angelo
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机构:
Milano Bicocca Univ, Sch Med & Surg, Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Racioppi, Angelo
[2
]
Nava, Stefano
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 1, Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Nava, Stefano
[3
]
Soriano, Francesco
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 1, Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Soriano, Francesco
[3
]
Piccaluga, Emanuela
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 1, Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Piccaluga, Emanuela
[3
]
Piccalo, Giacomo
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 1, Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Piccalo, Giacomo
[3
]
Oreglia, Jacopo
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 1, Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Oreglia, Jacopo
[3
]
Vallerio, Paola
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Vallerio, Paola
[1
]
Pirola, Roberto
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Pirola, Roberto
[1
]
De Chiara, Benedetta
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
De Chiara, Benedetta
[1
]
Oliva, Fabrizio
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 1, Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Oliva, Fabrizio
[3
]
Moreo, Antonella
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Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Moreo, Antonella
[1
]
Valsecchi, Maria Grazia
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Univ Milano Bicocca, Bicocca Ctr Bioinformat, Biostat & Bioimaging B4 Ctr, Sch Med & Surg, Monza, ItalyOsped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
Valsecchi, Maria Grazia
[4
]
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Giannattasio, Cristina
[1
,2
]
机构:
[1] Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Piazza Osped Maggiore 3, I-20159 Milan, Italy
[2] Milano Bicocca Univ, Sch Med & Surg, Milan, Italy
[3] Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 1, Milan, Italy
[4] Univ Milano Bicocca, Bicocca Ctr Bioinformat, Biostat & Bioimaging B4 Ctr, Sch Med & Surg, Monza, Italy
Background and aims: Uric Acid (UA) has been related to the development of CardioVascular (CV) events in patients affected by Chronic Coronary Syndromes (CCS). Among various hypothesis, two arise: UA may negatively act on coronary artery determining a higher degree of atherosclerotic disease, and/or on heart determining a higher prevalence of diastolic dysfunction. Both the above hypothesized effects are object of our investigation. Methods and results: 231 patients who were admitted to the cardiological department of the Niguarda Hospital (Milan, Italy) for CCS from January 2017 to June 2018 were enrolled. Coronary atherosclerotic burden was evaluated from coronary angiography as the number and type of involved vessels, as well as with both Gensini and Syntax scores. All subjects underwent a complete echocardiogram. At unadjusted and adjusted/multivariable analysis, UA levels were not significantly associated with variables analysed from the coronary angiography (number and type of vessels involved, neither the Gensini and Syntax scores) as well as with echocardiographic parameters regarding systolic and diastolic function. Conclusions: In conclusion, the main finding of our work is the absence of a role for UA in determining coronary arteries disease as well as LV diastolic dysfunction in CCS subjects. Taking together the results of previous studies with ours, we hypothesize that UA could act on heart (both on coronary arteries and on LV function) in an early phase of the disease, whereas while in the advanced stages other factors (previous myocardial infarction, previous myocardial revascularization and so on) may overshadow its effects. (c) 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
机构:
Department of Cardiology,Peking University Third Hospital
Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health and Key Laboratory of Molecular Cardiovascular Sciences,Ministry of EducationDepartment of Cardiology,Peking University Third Hospital
Yu Jie
Han Jiangli
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机构:
Department of Cardiology,Peking University Third Hospital
Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health and Key Laboratory of Molecular Cardiovascular Sciences,Ministry of EducationDepartment of Cardiology,Peking University Third Hospital
Han Jiangli
Mao Jieming
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机构:
Department of Cardiology,Peking University Third Hospital
Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health and Key Laboratory of Molecular Cardiovascular Sciences,Ministry of EducationDepartment of Cardiology,Peking University Third Hospital
Mao Jieming
Guo Lijun
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机构:
Department of Cardiology,Peking University Third Hospital
Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health and Key Laboratory of Molecular Cardiovascular Sciences,Ministry of EducationDepartment of Cardiology,Peking University Third Hospital
Guo Lijun
Gao Wei
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机构:
Department of Cardiology,Peking University Third Hospital
Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health and Key Laboratory of Molecular Cardiovascular Sciences,Ministry of EducationDepartment of Cardiology,Peking University Third Hospital
机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL USAUniv Alabama Birmingham, Dept Med, Birmingham, AL USA
Sharifov, Oleg F.
Murphy, John M.
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Univ Alabama Birmingham, Dept Med, Birmingham, AL USAUniv Alabama Birmingham, Dept Med, Birmingham, AL USA
Murphy, John M.
Perry, Gilbert J.
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机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL USA
Vet Affairs Med Ctr, Birmingham, AL USAUniv Alabama Birmingham, Dept Med, Birmingham, AL USA
Perry, Gilbert J.
Tallaj, Jose
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机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL USA
Vet Affairs Med Ctr, Birmingham, AL USAUniv Alabama Birmingham, Dept Med, Birmingham, AL USA
Tallaj, Jose
Denney, Thomas S., Jr.
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机构:
Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USAUniv Alabama Birmingham, Dept Med, Birmingham, AL USA
Denney, Thomas S., Jr.
Prabhu, Sumanth D.
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机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL USA
Vet Affairs Med Ctr, Birmingham, AL USAUniv Alabama Birmingham, Dept Med, Birmingham, AL USA
Prabhu, Sumanth D.
Gupta, Himanshu
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机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL USA
Vet Affairs Med Ctr, Birmingham, AL USA
Valley Hlth Syst, Ridgewood, NJ USAUniv Alabama Birmingham, Dept Med, Birmingham, AL USA
Gupta, Himanshu
Lloyd, Steven G.
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机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL USA
Vet Affairs Med Ctr, Birmingham, AL USAUniv Alabama Birmingham, Dept Med, Birmingham, AL USA
Lloyd, Steven G.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES,
2021,
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