Molecular correlates of influenza A H5N1 virus pathogenesis in mice

被引：171

作者：

Katz, JM ^{[1
]}

Lu, XH ^{[1
]}

Tumpey, TM ^{[1
]}

Smith, CB ^{[1
]}

Shaw, MW ^{[1
]}

Subbarao, K ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Influenza Branch, Div Viral & Rickettsial Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 22期

关键词：

D O I：

10.1128/JVI.74.22.10807-10810.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Highly pathogenic avian influenza A H5N1 viruses caused an outbreak of human respiratory illness in Hong Kong. Of 15 human H5N1 isolates characterized, nine displayed a high-, five a low-, and one an intermediate-pathogenicity phenotype in the BALB/c mouse model. Sequence analysis determined that five specific amino acids in four proteins correlated with pathogenicity in mice. Alone or in combination, these specific residues are the likely determinants of virulence of human H5N1 influenza viruses in this model.

引用

页码：10807 / 10810

页数：4

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