Molecular correlates of influenza A H5N1 virus pathogenesis in mice

被引：171
|
作者：
Katz, JM [1 ]
Lu, XH [1 ]
Tumpey, TM [1 ]
Smith, CB [1 ]
Shaw, MW [1 ]
Subbarao, K [1 ]
机构：
[1] Ctr Dis Control & Prevent, Influenza Branch, Div Viral & Rickettsial Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA
来源：
JOURNAL OF VIROLOGY | 2000年 / 74卷 / 22期
关键词：
D O I：
10.1128/JVI.74.22.10807-10810.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Highly pathogenic avian influenza A H5N1 viruses caused an outbreak of human respiratory illness in Hong Kong. Of 15 human H5N1 isolates characterized, nine displayed a high-, five a low-, and one an intermediate-pathogenicity phenotype in the BALB/c mouse model. Sequence analysis determined that five specific amino acids in four proteins correlated with pathogenicity in mice. Alone or in combination, these specific residues are the likely determinants of virulence of human H5N1 influenza viruses in this model.
引用
收藏
页码：10807 / 10810
页数：4
相关论文
共 50 条
  • [1] Molecular correlates of influenza A H5N1 virus pathogenesis in mice
    Subbarao, K
    Lu, X
    Tumpey, TM
    Smith, CB
    Shaw, MW
    Katz, JM
    OPTIONS FOR THE CONTROL OF INFLUENZA IV, 2001, 1219 : 595 - 600
  • [2] Molecular pathogenesis of H5N1 influenza virus infections
    Neumann, Gabriele
    Shinya, Kyoko
    Kawaoka, Yoshihiro
    ANTIVIRAL THERAPY, 2007, 12 (04) : 617 - 626
  • [3] Pathogenesis of Infectious Disease of Mice Caused by H5N1 Avian Influenza Virus
    V. A. Evseenko
    K. A. Sharshov
    E. K. Bukin
    A. V. Zaykovskaya
    V. A. Ternovoy
    G. M. Ignatyev
    A. M. Shestopalov
    S. V. Netesov
    V. A. Shkurupiy
    I. G. Drozdov
    Bulletin of Experimental Biology and Medicine, 2008, 146 : 766 - 769
  • [4] Pathogenesis of Infectious Disease of Mice Caused by H5N1 Avian Influenza Virus
    Evseenko, V. A.
    Sharshov, K. A.
    Bukin, E. K.
    Zaykovskaya, A. V.
    Ternovoy, V. A.
    Ignatyev, G. M.
    Shestopalov, A. M.
    Netesov, S. V.
    Shkurupiy, V. A.
    Drozdov, I. G.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 146 (06) : 766 - 769
  • [5] Avian influenza H5N1: an update on molecular pathogenesis
    Wang HongLiang
    Jiang ChengYu
    SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 2009, 52 (05): : 459 - 463
  • [6] Avian influenza H5N1:an update on molecular pathogenesis
    WANG HongLiang & JIANG ChengYu National Key Laboratory of Medical Molecular Biology
    Science in China(Series C:Life Sciences), 2009, (05) : 459 - 463
  • [7] Avian influenza H5N1: an update on molecular pathogenesis
    HongLiang Wang
    ChengYu Jiang
    Science in China Series C: Life Sciences, 2009, 52 : 459 - 463
  • [8] Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans
    Uiprasertkui, Mongkol
    Kitphati, Rungrueng
    Piuthavathana, Pilaipan
    Kriwong, Romchat
    Kongchanagul, Alita
    Ungchusak, Kumnuan
    Angkasekwinai, Suwimon
    Chokephaibulkit, Kulkanya
    Srisook, Kanittar
    Vanprapar, Nirun
    Auewarakul, Prasert
    EMERGING INFECTIOUS DISEASES, 2007, 13 (05) : 708 - 712
  • [9] A New Determinant of H5N1 Influenza Virus Pathogenesis in Mammals
    Dermody, Terence S.
    Sandri-Goldin, Rozanne M.
    Shenk, Thomas
    JOURNAL OF VIROLOGY, 2013, 87 (09) : 4795 - 4796
  • [10] Pathogenesis of influenza A (H5N1) virus infection in a primate model
    Rimmelzwaan, GF
    Kuiken, T
    van Amerongen, G
    Bestebroer, TM
    Fouchier, RAM
    Osterhaus, ADME
    JOURNAL OF VIROLOGY, 2001, 75 (14) : 6687 - 6691
12345