Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes

被引：26
|
作者：
Kozawa, Junji [1 ]
Okita, Kohei [1 ]
Imagawa, Akihisa [1 ]
Iwahashi, Hiromi [1 ]
Holst, Jens J. [2 ]
Yamagata, Kazuya [3 ]
Shimomura, Iichiro [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka, Japan
[2] Univ Copenhagen, Panum Inst, Dept Biomed Sci, DK-2200 Copenhagen, Denmark
[3] Kumamoto Univ, Fac Med & Pharmaceut Sci, Dept Med Biochem, Kumamoto, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 393卷 / 03期
关键词：
GLP-1; GIP; Diabetes; Incretin; Obese; GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY POLYPEPTIDE; DEPENDENT INSULINOTROPIC POLYPEPTIDE; BETA-CELL MASS; GLUCOSE; HUMANS; GLP-1;
D O I：
10.1016/j.bbrc.2010.01.134
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
secretion and effect on insulin secretion are not fully understood in patients with type 2 diabetes. We investigated incretin and insulin secretion after meal intake in obese and non-obese Japanese patients with type 2 diabetes compared to non-diabetic subjects. Nine patients with type 2 diabetes and 5 non-diabetic subjects were recruited for this study. Five diabetic patients were obese (BMI >= 25) and 4 patients were non-obese (BMI < 25). In response to a mixed meal test, the levels of immunoreactive insulin during 15-90 min and C-peptide during 0-180 min in non-obese patients were significantly lower than those in obese patients. Total GLP-1 and active GIP levels showed no significant difference between obese and non-obese patients throughout the meal tolerance test. In addition, there were no significant differences between diabetic patients and non-diabetic subjects. In conclusion, incretin secretion does not differ between Japanese obese and non-obese patients with type 2 diabetes and non-diabetic subjects. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：410 / 413
页数：4
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