Microwave-Assisted, Metal-Free, Base-Mediated C-N Bond Formation/Cleavage: Synthesis of Benzimidazo[1,2-a]quinazoline Derivatives

被引：18

作者：

Kumar, Prashant ^{[1
]}

Singh, Anil K. ^{[1
]}

Bahadur, Vijay ^{[1
,6
]}

Len, Christophe ^{[2
,3
]}

Richards, Nigel G. J. ^{[4
,5
]}

Parmar, Virinder S. ^{[1
,4
]}

Van der Eycken, Erik V. ^{[6
]}

Singh, Brajendra K. ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India

[2] UTC, Univ Paris 04, ESCOM, CS 60319, F-60203 Compiegne, France

[3] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

[4] Indiana Univ Purdue Univ IUPUI, Dept Chem & Chem Biol, 402 North Blackford St, Indianapolis, IN 46202 USA

[5] Cardiff Univ, Coll Phys Sci & Engn, Sch Chem, Pk Pl, Cardiff CF10 3AT, S Glam, Wales

[6] Katholieke Univ Leuven, Univ Leuven, Dept Chem, LOMAC, Celestijnenlaan 200F, B-3001 Leuven, Belgium

来源：

ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2016年 / 4卷 / 04期

关键词：

Short reaction time; Base-promoted; Microwave irradiation; Intramolecular addition/elimination; Quinazoline-fused benzimidazoles; NUCLEOPHILIC AROMATIC-SUBSTITUTION;

D O I：

10.1021/acssuschemeng.5b01669

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel, rapid, and efficient microwave-assisted, metal-free, base-mediated approach has been developed for the construction of benzimidazo[1,2-a]quinazolines from readily available building blocks. This synthetic strategy affords a diverse range of benzimidazo[1,2-a]quinazoline derivatives in moderate to good yields.

引用

页码：2206 / 2210

页数：5

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