DNA recognition by the Salmonella enterica serovar Typhimurium transcription factor SlyA

被引：7
|
作者：
Haider, Fouzia [1 ]
Lithgow, James K. [1 ]
Stapleton, Melanie R. [1 ]
Norte, Valia A. [1 ]
Roberts, Ruth E. [1 ]
Green, Jeffrey [1 ]
机构：
[1] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England
来源：
INTERNATIONAL MICROBIOLOGY | 2009年 / 11卷 / 04期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
Salmonella; gene regulation; DNA binding; SlyA; MarR; OhrR; ESCHERICHIA-COLI; CRYSTAL-STRUCTURE; H-NS; DIFFERENTIAL REGULATION; EXPRESSION; RESISTANCE; REGULATOR; PROTEINS; IDENTIFICATION; VIRULENCE;
D O I：
10.2436/20.1501.01.68
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The Salmonella regulatory protein SlyA is implicated in virulence, survival in macrophages and resistance to oxidative stress and anti-microbial peptides. SlyA is a member of the MarR family of winged-helix transcription factors. Systematic mutational analysis of the SlyA operator sequence and of the predicted DNA-binding region of SlyA shows that no single base pair in the palindromic SlyA operator sequence is essential for DNA binding, and identifies amino acid residues required to allow SlyA to recognise DNA. Combining the structure-function studies described here and elsewhere with the structures of MarR family proteins suggests a possible model for regulation of SlyA binding to DNA. [Int Microbiol 2008; 11(4):245-250]
引用
收藏
页码：245 / 250
页数：6
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