The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection

被引：10
|
作者：
Tomita, Yuriko [1 ]
Matsuyama, Shutoku [1 ]
Fukuhara, Hideo [2 ,3 ]
Maenaka, Katsumi [2 ,3 ]
Kataoka, Hiroaki [4 ]
Hashiguchi, Takao [5 ]
Takeda, Makoto [1 ]
机构：
[1] Natl Inst Infect Dis, Dept Virol 3, Tokyo, Japan
[2] Hokkaido Univ, Fac Pharmaceut Sci, Lab Biomol Sci, Sapporo, Hokkaido, Japan
[3] Hokkaido Univ, Fac Pharmaceut Sci, Ctr Res & Educ Drug Discovery, Sapporo, Hokkaido, Japan
[4] Univ Miyazaki, Dept Pathol, Fac Med, Sect Oncopathol & Regenerat Biol, Miyazaki, Japan
[5] Kyoto Univ, Inst Frontier Life & Med Sci, Lab Med Virol, Kyoto, Japan
来源：
JOURNAL OF VIROLOGY | 2021年 / 95卷 / 12期
关键词：
SARS-CoV-2; HAI-2; TMPRSS2; ENTRY;
D O I：
10.1128/JVI.00434-21
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [31] Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
    Lukas Wettstein
    Tatjana Weil
    Carina Conzelmann
    Janis A. Müller
    Rüdiger Groß
    Maximilian Hirschenberger
    Alina Seidel
    Susanne Klute
    Fabian Zech
    Caterina Prelli Bozzo
    Nico Preising
    Giorgio Fois
    Robin Lochbaum
    Philip Maximilian Knaff
    Volker Mailänder
    Ludger Ständker
    Dietmar Rudolf Thal
    Christian Schumann
    Steffen Stenger
    Alexander Kleger
    Günter Lochnit
    Benjamin Mayer
    Yasser B. Ruiz-Blanco
    Markus Hoffmann
    Konstantin M. J. Sparrer
    Stefan Pöhlmann
    Elsa Sanchez-Garcia
    Frank Kirchhoff
    Manfred Frick
    Jan Münch
    Nature Communications, 12
  • [32] A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
    Tirosh Shapira
    I. Abrrey Monreal
    Sébastien P. Dion
    David W. Buchholz
    Brian Imbiakha
    Andrea D. Olmstead
    Mason Jager
    Antoine Désilets
    Guang Gao
    Mathias Martins
    Thierry Vandal
    Connor A. H. Thompson
    Aaleigha Chin
    William D. Rees
    Theodore Steiner
    Ivan Robert Nabi
    Eric Marsault
    Julie Sahler
    Diego G. Diel
    Gerlinde R. Van de Walle
    Avery August
    Gary R. Whittaker
    Pierre-Luc Boudreault
    Richard Leduc
    Hector C. Aguilar
    François Jean
    Nature, 2022, 605 : 340 - 348
  • [33] Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein
    Sagar, Satish
    Rathinavel, Ashok Kumar
    Lutz, William E.
    Struble, Lucas R.
    Khurana, Surender
    Schnaubelt, Andy T.
    Mishra, Nitish Kumar
    Guda, Chittibabu
    Palermo, Nicholas Y.
    Broadhurst, Mara J.
    Hoffmann, Tobias
    Bayles, Kenneth W.
    Reid, St. Patrick M.
    Borgstahl, Gloria E. O.
    Radhakrishnan, Prakash
    CLINICAL AND TRANSLATIONAL MEDICINE, 2021, 11 (02):
  • [34] Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection
    Uranaka, Tsukasa
    Kashio, Akinori
    Ueha, Rumi
    Sato, Taku
    Bing, Han
    Ying, Gao
    Kinoshita, Makoto
    Kondo, Kenji
    Yamasoba, Tatsuya
    LARYNGOSCOPE, 2021, 131 (06): : E2013 - E2017
  • [35] A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
    Shapira, Tirosh
    Monreal, I. Abrrey
    Dion, Sebastien P.
    Buchholz, David W.
    Imbiakha, Brian
    Olmstead, Andrea D.
    Jager, Mason
    Desilets, Antoine
    Gao, Guang
    Martins, Mathias
    Vandal, Thierry
    Thompson, Connor A. H.
    Chin, Aaleigha
    Rees, William D.
    Steiner, Theodore
    Nabi, Ivan Robert
    Marsault, Eric
    Sahler, Julie
    Diel, Diego G.
    Van de Walle, Gerlinde R.
    August, Avery
    Whittaker, Gary R.
    Boudreault, Pierre-Luc
    Leduc, Richard
    Aguilar, Hector C.
    Jean, Francois
    NATURE, 2022, 605 (7909) : 340 - +
  • [36] ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection
    Zhou, Lingli
    Xu, Zhenhua
    Castiglione, Gianni M.
    Soiberman, Uri S.
    Eberhart, Charles G.
    Duh, Elia J.
    OCULAR SURFACE, 2020, 18 (04): : 537 - 544
  • [37] Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
    Padmanabhan, Pranesh
    Desikan, Rajat
    Dixit, Narendra M.
    PLOS COMPUTATIONAL BIOLOGY, 2020, 16 (12)
  • [38] Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation
    Bryan J. Fraser
    Serap Beldar
    Almagul Seitova
    Ashley Hutchinson
    Dhiraj Mannar
    Yanjun Li
    Daniel Kwon
    Ruiyan Tan
    Ryan P. Wilson
    Karoline Leopold
    Sriram Subramaniam
    Levon Halabelian
    Cheryl H. Arrowsmith
    François Bénard
    Nature Chemical Biology, 2022, 18 : 963 - 971
  • [39] Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2
    Ou, Tianling
    Mou, Huihui
    Zhang, Lizhou
    Ojha, Amrita
    Choe, Hyeryun
    Farzan, Michael
    PLOS PATHOGENS, 2021, 17 (01)
  • [40] Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation
    Fraser, Bryan J.
    Beldar, Serap
    Seitova, Almagul
    Hutchinson, Ashley
    Mannar, Dhiraj
    Li, Yanjun
    Kwon, Daniel
    Tan, Ruiyan
    Wilson, Ryan P.
    Leopold, Karoline
    Subramaniam, Sriram
    Halabelian, Levon
    Arrowsmith, Cheryl H.
    Benard, Francois
    NATURE CHEMICAL BIOLOGY, 2022, 18 (09) : 963 - +
12345