Synthesis of spiroketal fragment of ossamycin via Prins cyclization

被引：7

作者：

Yadav, J. S. ^{[1
]}

Rahman, Md. Ataur ^{[1
]}

Reddy, N. Mallikarjuna ^{[1
]}

Prasad, A. R. ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Ctr Semiochem, Acad Sci & Innovat Res AcSIR, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 02期

关键词：

Natural products; Antitumour antibiotic; Prins cyclization; Reductive opening; Spiroketals; STEREOSELECTIVE-SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; REDUCTIVE CLEAVAGE; CYTOVARICIN; OLIGOMYCIN; SEGMENT;

D O I：

10.1016/j.tetlet.2014.11.097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of spiroketal fragment of an antitumour antibiotic, ossamycin is described. Coupling of aldehyde and alkyne fragments followed by spiroketalization has afforded the spiroketal sub unit of ossamycin. Both the sub targets were constructed via Prins cyclization. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：365 / 367

页数：3

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