Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity

被引：53
|
作者：
Mantyh, PW [1 ]
Hunt, SP
机构：
[1] Univ Minnesota, Neurosyst Ctr, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Dep Prevent Sci, Minneapolis, MN 55455 USA
[4] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
[5] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA
[6] VA Med Ctr, Minneapolis, MN 55417 USA
[7] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England
来源：
TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 10期
关键词：
D O I：
10.1016/j.tins.2004.07.007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The neurokinin-1 receptor is expressed by lamina I projection neurons of the spinal cord that are crucial for regulating pain behavior. These neurons are nocispecific, support long-term potentiation and appear to downregulate the K(+)-Cl(-) exporter channel KCC2 following peripheral nerve damage, leading to increased excitability. These lamina I neurons project to the brainstem and thalamus and modulate descending inhibitory and excitatory pathways to the dorsal horn that regulate nociceptive traffic.
引用
收藏
页码：582 / 584
页数：3
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