Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity

被引：53

作者：

Mantyh, PW ^{[1
]}

Hunt, SP

机构：

[1] Univ Minnesota, Neurosyst Ctr, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dep Prevent Sci, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA

[6] VA Med Ctr, Minneapolis, MN 55417 USA

[7] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 10期

关键词：

D O I：

10.1016/j.tins.2004.07.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurokinin-1 receptor is expressed by lamina I projection neurons of the spinal cord that are crucial for regulating pain behavior. These neurons are nocispecific, support long-term potentiation and appear to downregulate the K(+)-Cl(-) exporter channel KCC2 following peripheral nerve damage, leading to increased excitability. These lamina I neurons project to the brainstem and thalamus and modulate descending inhibitory and excitatory pathways to the dorsal horn that regulate nociceptive traffic.

引用

页码：582 / 584

页数：3

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