Direct asymmetric aldol reaction catalyzed by simple prolinamide phenols

被引：94

作者：

Fu, Yu-Qin ^{[1
]}

Li, Zai-Chun ^{[1
]}

Ding, Ll-Na ^{[1
]}

Tao, Jing-Chao ^{[1
]}

Zhang, Sheng-Hong ^{[1
]}

Tang, Ming-Sheng ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, New Drug Res & Dev Ctr, Zhengzhou 450052, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 24期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.tetasy.2006.12.008

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Simple prolinamides 1a-f were synthesized, and their catalytic effects on the direct asymmetric aldol reactions in organic solvents and in water were evaluated. Prolinamide phenols 1a-d were found to be effective catalysts for the reaction of aromatic aldehydes with cyclohexanone in neat ketone and in water. The anti-aldol products were obtained with up to 98/2 anti/syn ratio and 96% ee in neat ketone, 98/2 anti/syn ratio and 99% ee in water, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3351 / 3357

页数：7

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